VALUE OF SEROLOGICAL TESTS (IGA, IGG, IGM) IN DIAGNOSIS OF TUBERCULOSIS

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GHADIRI S.K.; IZADI B.; AFSHARIAN MANDANA; REZAEI MANSOUR; NAMDARI S.A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2007 | Volume:11 | Issue:35 Page(s): 55-58

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Title

VALUE OF SEROLOGICAL TESTS (IGA, IGG, IGM) IN DIAGNOSIS OF TUBERCULOSIS

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Keywords

TUBERCULOSISQ3

TBQ3

A-60 ANTIGENQ3

SEROLOGY-ELISAQ3

Abstract

Objective and background: TUBERCULOSIS (TB) is one of the most common infection diseases through the word. Diagnosis of TB in most cases is difficult and often needs Para clinical studies. Measuring immunoglobulin against A-60 ANTIGENs of TB microorganisms is one of these methods. This study's aim is analyzing of diagnostic value of serologic tests (lgA, IgM, IgG) against A-60 ANTIGEN in TUBERCULOSIS.Material and Methods: All of the cases with pulmonary and extra pulmonary TUBERCULOSIS were tested and IgM, IgA and IgG against A-60 ANTIGEN were measured. These immunoglobulin also were measured in control group without any disease. Cases group included 176 patients (124 patients with smear positive pulmonary TB and 52 patients with extra pulmonary TB). Control group Included 283 people without any obvious disease. Results: Sensitivity of IgM, IgG and IgA tests was 15%, 25%, 40% and their specificity was 100%, 75% and 90% receptivity. Positive predictive value (PPY) was 100%, 57% and 72% and negative predictive value (NPY) was 65%, 72% and 70% respectively. Combination of immunoglobulins increased sensitivity; the highest sensitivity was observed in combination of IgG and IgA.Conclusion: This study revealed that ELISA method in measuring Immunoglobulins is useful. Although its sensitivity is not high, but with combination of Immunoglubolins sensitivity is acceptable.

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APA: Copy

GHADIRI, S.K., IZADI, B., AFSHARIAN, MANDANA, REZAEI, MANSOUR, & NAMDARI, S.A.. (2007). VALUE OF SEROLOGICAL TESTS (IGA, IGG, IGM) IN DIAGNOSIS OF TUBERCULOSIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(35), 55-58. SID. https://sid.ir/paper/52937/en

Vancouver: Copy

GHADIRI S.K., IZADI B., AFSHARIAN MANDANA, REZAEI MANSOUR, NAMDARI S.A.. VALUE OF SEROLOGICAL TESTS (IGA, IGG, IGM) IN DIAGNOSIS OF TUBERCULOSIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2007;11(35):55-58. Available from: https://sid.ir/paper/52937/en

IEEE: Copy

S.K. GHADIRI, B. IZADI, MANDANA AFSHARIAN, MANSOUR REZAEI, and S.A. NAMDARI, “VALUE OF SEROLOGICAL TESTS (IGA, IGG, IGM) IN DIAGNOSIS OF TUBERCULOSIS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 35, pp. 55–58, 2007, [Online]. Available: https://sid.ir/paper/52937/en

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