SEQUENCING ANALYSIS OF HELICOBACTER PYLORI 3 REGION OF CAGA GENE IN ISOLATES FROM DYSPEPTIC PATIENTS

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SHOKRZADEH L.; BAGHAEI K.; TAJADIN E.; JAFARI F.; DABIRI H.; SAYADI S.; ZALI M.R.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2010 | Volume:15 | Issue:50 Page(s): 25-31

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Title

SEQUENCING ANALYSIS OF HELICOBACTER PYLORI 3 REGION OF CAGA GENE IN ISOLATES FROM DYSPEPTIC PATIENTS

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Keywords

SEQUENCINGQ2

HELICOBACTER PYLORIQ3

CAGAQ2

Abstract

Background and objectives: HELICOBACTER PYLORI contributes to the development of peptic ulcers and gastric cancer. The most well-known virulence factor of HELICOBACTER PYLORI, CAGA, is translocated into gastric epithelial cells and localizes to the inner surface of the plasma membrane, in which it undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif. Four segments flanking the EPIYA motifs, EPIYA-A, -B, -C, or -D, were reported to play important roles in H. pylori-related gastroduodenal pathogenesis. The aim of this study was to determine the roles of EPIYA segments in gastroduodenal pathogenesis in an Iranian population.Materials and methods: A total of 92 CAGA-positive Iranian strains isolated from dyspepsia patients with non-ulcer dyspepsia (n=77), peptic ulcer (n=11) and gastric cancer (n=4) were studied. The EPIYA motif genotyping was determined by polymerase chain reaction and SEQUENCING.Results: 86 (93.5%) strains had three copies of EPIYA (ABC type), three (3.3%) had four copies (ABCC type) and three (3.3%) had two copies (AB type). The alignment of the deduced protein sequences confirmed that there were no East Asian type EPIYA-D sequences (EPIYATIDFDEANQAG) in Iranian strains.Conclusion: The structure of the 3 region of the CAGA gene in Iranian strains was Western type. Although we could not find differences between EPIYA types and clinical outcomes, low prevalence of strains with multiple EPIYA-C segments might be reasons for low incidence of gastric cancer in Iran.

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APA: Copy

SHOKRZADEH, L., BAGHAEI, K., TAJADIN, E., JAFARI, F., DABIRI, H., SAYADI, S., & ZALI, M.R.. (2010). SEQUENCING ANALYSIS OF HELICOBACTER PYLORI 3 REGION OF CAGA GENE IN ISOLATES FROM DYSPEPTIC PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 15(50), 25-31. SID. https://sid.ir/paper/53001/en

Vancouver: Copy

SHOKRZADEH L., BAGHAEI K., TAJADIN E., JAFARI F., DABIRI H., SAYADI S., ZALI M.R.. SEQUENCING ANALYSIS OF HELICOBACTER PYLORI 3 REGION OF CAGA GENE IN ISOLATES FROM DYSPEPTIC PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2010;15(50):25-31. Available from: https://sid.ir/paper/53001/en

IEEE: Copy

L. SHOKRZADEH, K. BAGHAEI, E. TAJADIN, F. JAFARI, H. DABIRI, S. SAYADI, and M.R. ZALI, “SEQUENCING ANALYSIS OF HELICOBACTER PYLORI 3 REGION OF CAGA GENE IN ISOLATES FROM DYSPEPTIC PATIENTS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 15, no. 50, pp. 25–31, 2010, [Online]. Available: https://sid.ir/paper/53001/en

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