THE EFFECT OF AEROBIC TRAINING IN DIFFERENT INTENSITIES ON MTDNA DELETION IN THE ‎SOLEUS OF RATS

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JAFARI A.A.F.; HOSSEINPOUR FEYZI M.A.; HOUSHMAND M.; RAVASI A.A.; MONTAZERI M.

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Journal: Year:2004 | Volume:- | Issue:18 Page(s): 97-116

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Title

THE EFFECT OF AEROBIC TRAINING IN DIFFERENT INTENSITIES ON MTDNA DELETION IN THE ‎SOLEUS OF RATS

Author(s)

Keywords

AEROBIC TRAINING

OXIDATIVE STRESS

ROS

AGING

MTDNA

MITOCHONDRIAL DELETION

Abstract

Based on mitochondrial AGING theory, OXIDATIVE STRESS plays a major role in AGING and ‎age related degenerative diseases. Since oxygen consumption and ROS (reactive ‎oxygen species) rate increase during aerobic exercise, we supposed that heavy aerobic ‎training can lead to enhance MTDNA deletion. Two experimental groups of adult male ‎Wistar 14848 rats with 2 month-age were trained by running on a treadmill for 3 ‎months (5day/wk, E40: N=10, 40 m/min, 20 min, E20: N=10, 20 m/min, 40 min, ‎and slob=6%). MTDNA deletion of soleus muscle in these groups were compared with ‎that in two control groups (Con1: N=10, aged 2 months and Con2" N=10, aged 5 ‎months) and two sedentary groups that participated only in aerobic exercises at the ‎end of the study (CE40: N=10, 40m/min, 20min, CE20: N=10, 20 m/min, ‎‎40 min, and slob=6%). Multiplex PCR products based on the agar (2%) indicated that ‎mtDNA deletion (4.6kb0 induced by heavy AEROBIC TRAINING in E40 group. This ‎deletion was not shown in other groups. This result was confirmed by sequencing ‎analysis‏.‏

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APA: Copy

JAFARI, A.A.F., HOSSEINPOUR FEYZI, M.A., HOUSHMAND, M., RAVASI, A.A., & MONTAZERI, M.. (2004). THE EFFECT OF AEROBIC TRAINING IN DIFFERENT INTENSITIES ON MTDNA DELETION IN THE ‎SOLEUS OF RATS. HARAKAT, -(18), 97-116. SID. https://sid.ir/paper/530134/en

Vancouver: Copy

JAFARI A.A.F., HOSSEINPOUR FEYZI M.A., HOUSHMAND M., RAVASI A.A., MONTAZERI M.. THE EFFECT OF AEROBIC TRAINING IN DIFFERENT INTENSITIES ON MTDNA DELETION IN THE ‎SOLEUS OF RATS. HARAKAT[Internet]. 2004;-(18):97-116. Available from: https://sid.ir/paper/530134/en

IEEE: Copy

A.A.F. JAFARI, M.A. HOSSEINPOUR FEYZI, M. HOUSHMAND, A.A. RAVASI, and M. MONTAZERI, “THE EFFECT OF AEROBIC TRAINING IN DIFFERENT INTENSITIES ON MTDNA DELETION IN THE ‎SOLEUS OF RATS,” HARAKAT, vol. -, no. 18, pp. 97–116, 2004, [Online]. Available: https://sid.ir/paper/530134/en

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