During a soccer match, players exercised at a relatively high intensity. It is therefore not surprising that fatigue occurs causing performance to fall off in the laer stages o f the match in the second half. Since decision-making as well as technical and tactical aspects are important elements in soccer, towards the end of the match fatigue can cause deteriorations in mental performance. Eric Newsholme et al. 91987) were the first to hypothesize such a role for brain Serotonin (5-HT).
Recently hypotheses have been developed and there has been an interest in the possible role of the CNS in fatigue. A few mechanisms have been suggested to cause central fatigue such as changes in neurotransmitters of serotonin, dopamine and acetylcholine. An increase in 5-HT, DA and ACh synthesis and metabolism typically occur in response to an increase in delivery of blood-borne Trp, Tyr and cholin to the brain and central serotonergic, dopaminergic and cholinergic systems activated by stress, exercise, eating, supplementation and medication. Thus fatigue could affect all behavioral and physiological functions that could positively or negatively affect power or endurance of performance. Thirty adult male soccer players were divided into five groups randomly. Placebo group and experimental group whose ingestion flavored water, glucose, BCAAs, lecithin and hydroalchoholic extract of sage, 2.5h before and during soccer-specific intermittent running protocol.
The peripheral serotonin and dopamine levels were determined through venous blood samples collected throughout the last 2.5 hours, half-time and immediately after soccer-specific intermittent running protocol. Subjects also completed the POMS, CWT, RPE, and measured exercise time to fatigue. Based on our observations that fatigue during soccer-specific intermittent protocol towards the end of the soccer match in adult male soccer players is associated with an increase in barin 5-HT and a reduction of brain dopamine, our working hypothesis is that a low ratio of 5-HT/DA and high ACh level in the brain prevent mental fatigue and subsequently enhance performance in soccer matches. Increased serotonergic activity may induce fatigue through inhibition of the dopaminergic system and or the reduction of motivation to perform. Furthermore, serotonergic activity can affect the hypothalamic-pituitary-adrenal axis, thermoregulation, pain, mood, motor coordination and other behaviors or perceptions depending on specific situations such as physical activity.