NICOTINIC ACID IN RETINAL VEIN OCCLUSION

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ABRISHAMI M.; ZAREEI GHANAVATI S.; BANAEE M.; AHMADIAN M.H.; MOUSAVI M.N.

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Journal: JOURNAL OF CURRENT OPHTHALMOLOGY Year:2005 | Volume:18 | Issue:3 Page(s): 64-74

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Title

NICOTINIC ACID IN RETINAL VEIN OCCLUSION

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Keywords

NICOTINIC ACIDQ4

NIACINQ4

RETINAL VEIN OCCLUSIONQ4

CRVOQ4

BRVOQ4

Abstract

Purpose: To evaluate the effect of NICOTINIC ACID (as a possible vasodilator) in treatment of RETINAL VEIN OCCLUSIONs (CRVO or BRVO).Setting: Mashad University of Medical Science (MUMS); Khatam-Al-Anbia eye hospital.Desigin: Prospective non-randomized pilot studyPatients & Methods: Twenty two eyes of 21 patients with CRVO or BRVO, participated to receive incremental doses of NIACIN starting from 300 mg/day up to 3g/day for 3 months.Main outcome measures: Changes in visual acuity, visual fields, amount of vascular congestion, hemorrhage and macular edema in fundus photographs, and systemic complications of NICOTINIC ACID.Results: Mean follow up was 8.6±2.7months. Mean BCVA was 0.11±0.14 before treatment, 0.12±0.11 (P=0.30) at 1 month and 0.27±0.22 (P=0.009) at 3 months after treatment. At last follow up visit, mean BCVA was 0.26±0.23 (P=0.02). All patients had resolution of hemorrhages, cotton wool spots, macular edema, disc edema, venous tortuosity and dilation on basis of fundus photographs, 3 months after treatment. MD index or automated primetry improved from -29±9 before treatment to -24±7 (P=0.007) at three months and -28±9 (P=0.01) in the last follow up. Four patients were lost to follow up before 3 months and two other patients were excluded due to hypersensitivity to NICOTINIC ACID and severe hyperglycemia. The only other notable side effect of NICOTINIC ACID was flushing which was well tolerated by all patients. Conclusion: NICOTINIC ACID treatment for 3 months led to significant clinical improvement in CRVO and BRVO. NIACIN, by induction of vasodilatation, may possibly provide enough time for collateral vessels to develop. NIACIN is well tolerated and is associated with mild systemic side effects.

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APA: Copy

ABRISHAMI, M., ZAREEI GHANAVATI, S., BANAEE, M., AHMADIAN, M.H., & MOUSAVI, M.N.. (2005). NICOTINIC ACID IN RETINAL VEIN OCCLUSION. JOURNAL OF CURRENT OPHTHALMOLOGY, 18(3), 64-74. SID. https://sid.ir/paper/53156/en

Vancouver: Copy

ABRISHAMI M., ZAREEI GHANAVATI S., BANAEE M., AHMADIAN M.H., MOUSAVI M.N.. NICOTINIC ACID IN RETINAL VEIN OCCLUSION. JOURNAL OF CURRENT OPHTHALMOLOGY[Internet]. 2005;18(3):64-74. Available from: https://sid.ir/paper/53156/en

IEEE: Copy

M. ABRISHAMI, S. ZAREEI GHANAVATI, M. BANAEE, M.H. AHMADIAN, and M.N. MOUSAVI, “NICOTINIC ACID IN RETINAL VEIN OCCLUSION,” JOURNAL OF CURRENT OPHTHALMOLOGY, vol. 18, no. 3, pp. 64–74, 2005, [Online]. Available: https://sid.ir/paper/53156/en

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