COMPARISON OF ANTI-INFLAMMATORY EFFECTS OF DEXAMETHASONE PHOSPHATE AND PREDNISOLONE ACETATE EYE DROPS AFTER ECCE+PCIOL SURGERY

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AKBARZADEH S.; PANAHI M.M.

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Journal: JOURNAL OF CURRENT OPHTHALMOLOGY Year:2002 | Volume:14 | Issue:1 Page(s): 43-49

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Title

COMPARISON OF ANTI-INFLAMMATORY EFFECTS OF DEXAMETHASONE PHOSPHATE AND PREDNISOLONE ACETATE EYE DROPS AFTER ECCE+PCIOL SURGERY

Author(s)

AKBARZADEH S. | PANAHI M.M. | Issue Writer Certificate

Keywords

CORTICOSTEROIDSQ4

EYEQ4

OPHTHALMIC SOLUTIONSQ4

PREDNISOLONEQ4

DEXAMETHASONEQ4

CATARACT EXTRACTIONQ4

ECCE+PCIOLQ4

Abstract

Introduction & Purpose: Control of inflammation after intra-ocular surgery is essential for success of surgery. Topical steroids are the most popular drugs used for this purpose. In this study, which was performed as a clinical trial, the effectiveness of PREDNISOLONE acetate 1% and DEXAMETHASONE phosphate 0.1 % EYE drops for control of intraocular inflammation after ECCE+PCIOL was compared. Two Iranian pharmaceutical companies manufactured both drugs.Material & Method: Anterior chamber (AC) cell and flare, injection and pain were used to evaluate inflammation in this study. All patients had senile cataract. Above parameters were evaluated on the 3rd, 7th and 14th daysafter surgery. The course of study was 16 months.Resuts: Eighty patients were studied (forty in each group). On the basis of the above-mentioned methods, there was no statistically difference in pain between two groups. (P value=0.351) There was statistically difference in EYE injection between two groups (P value=0.054). However on the 7th day mean injection in the DEXAMETHASONE group was 0.775 and in the PREDNISOLONE group was 0.450 whose difference was meaningful. (P value 0.012) There was not any statistically significant difference in AC cell between two groups. (P value 0.421) In the case of AC flare there wasn't any statistically difference between two groups. Although AC flare on the 3rd day was different in two groups: mean AC flare was 1.525 in DEXAMETHASONE group and 1.225 PREDNISOLONE group whose difference was statistically meaningful (P value=0.02).Conclusions: In general the two EYE drops, PREDNISOLONE acetate 1% and DEXAMETHASONE phosphate 0.1%, manufactured in Iran, had more or less similar effects on control of inflammation after ECCE+PCIOL.

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APA: Copy

AKBARZADEH, S., & PANAHI, M.M.. (2002). COMPARISON OF ANTI-INFLAMMATORY EFFECTS OF DEXAMETHASONE PHOSPHATE AND PREDNISOLONE ACETATE EYE DROPS AFTER ECCE+PCIOL SURGERY. JOURNAL OF CURRENT OPHTHALMOLOGY, 14(1), 43-49. SID. https://sid.ir/paper/53222/en

Vancouver: Copy

AKBARZADEH S., PANAHI M.M.. COMPARISON OF ANTI-INFLAMMATORY EFFECTS OF DEXAMETHASONE PHOSPHATE AND PREDNISOLONE ACETATE EYE DROPS AFTER ECCE+PCIOL SURGERY. JOURNAL OF CURRENT OPHTHALMOLOGY[Internet]. 2002;14(1):43-49. Available from: https://sid.ir/paper/53222/en

IEEE: Copy

S. AKBARZADEH, and M.M. PANAHI, “COMPARISON OF ANTI-INFLAMMATORY EFFECTS OF DEXAMETHASONE PHOSPHATE AND PREDNISOLONE ACETATE EYE DROPS AFTER ECCE+PCIOL SURGERY,” JOURNAL OF CURRENT OPHTHALMOLOGY, vol. 14, no. 1, pp. 43–49, 2002, [Online]. Available: https://sid.ir/paper/53222/en

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