THE EVALUATION OF PUPIL REFLEXOMETRY METHOD TO THE ADDRESS OF A SCREENING TEST FOR ANALYSIS OF OPIOID MISAPPLICATION AND COMPARISON IT WITH IMMUNOCHROMATOGRAPHY AND THIN LAGER CHROMATOGRAPHY (TLC) METHOD

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SOLTANINEZHAD K.; FARYADI M.; AKHGARI M.; FAZILATI MOHAMMAD

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Journal: Iranian Journal of Forensic Medicine Year:2006 | Volume:11 | Issue:4 Page(s): 190-194

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Title

THE EVALUATION OF PUPIL REFLEXOMETRY METHOD TO THE ADDRESS OF A SCREENING TEST FOR ANALYSIS OF OPIOID MISAPPLICATION AND COMPARISON IT WITH IMMUNOCHROMATOGRAPHY AND THIN LAGER CHROMATOGRAPHY (TLC) METHOD

Author(s)

SOLTANINEZHAD K. | FARYADI M. | AKHGARI M. | FAZILATI MOHAMMAD | Issue Writer Certificate

Keywords

PUPIL REFELEXOMETERYQ4

OPIOIDSQ3

SCREENING TESTQ3

FORENSIC TOXICOLOGYQ3

Abstract

Background & Aim: Addiction to opioid substances is a worldwide problem and identification of opioid abusers has an important role for preventing medical and social advers effects of theses substances. There are many methods for screening and analysis of opioid comparison with routine SCREENING TESTs. In biological samples e.g. immunochromatography and thin lager chromatography (TLC). These methods, in spite of some preferences like speediness and cheapness, have some shortcomings like invasive (need to take blood or urine samples) and need to chemical reagents. In recent years pupil reflexometry technology which its basis is to study and video record of pupil movement followed to optical stimulation and computer interpretation, is discussed in diagnosis of opioid misapplication. The advantages of this method are lack of need to biologic samples (like blood and urine), being immune of laboratory results from intention manipulations, the high level of speediness in reaching to the conclusions and determining opioid misapplication until 21 days after drug no consumption period. The mentioned cases particularly in legal toxicology are very important. There for we designed this study for evaluations of efficacy of pupil reflexometry as a screening method for opioid detection in abusers in comparison with routine SCREENING TESTs.Materials & Methods: This study was performed on 158 subjects who referred to FORENSIC TOXICOLOGY laboratory of Legal Medicine Organization (LMO). At first information query was filled for each individual who include information about gender, age, background of eye and nervous diseases, the history of consumed drugs and surgeries. In order to test, first of all each person was being in a calm position for from any voices and high flashes for 15 minutes. In this study pupil reflexometery was performed by (Iritech, DM-2010) urine samples were obtained for TLC and immunochromatography simultaneously.Results: In this study 158 (117 male and 41 female) subjects were tested. Age rang was between 22-69 years with average of 35.6±0.8 years. The results showed that in pupil reflexometery method 70 (44.30%) subjects had negative results and 88 (55.70%) subjects had positive results. In cases with pupil reflexometery negative results 3 (4.28%) subjects had positive results (false negative) and in cases with PUPIL REFELEXOMETERY positive results only 9 (10.23%) subjects had positive result in TLC. Conclusion: Pupil reflexometery is a suitable SCREENING TEST for negative cases but inpositive cases because of the presence of interfering factors such as the history of consumed drugs, eye and nervous diseases, is no valid as a SCREENING TEST. In legal cases performing of supplementary testing like thin larger chromatography (TLC) for analyzing of opioid misapplication is necessary.

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APA: Copy

SOLTANINEZHAD, K., FARYADI, M., AKHGARI, M., & FAZILATI, MOHAMMAD. (2006). THE EVALUATION OF PUPIL REFLEXOMETRY METHOD TO THE ADDRESS OF A SCREENING TEST FOR ANALYSIS OF OPIOID MISAPPLICATION AND COMPARISON IT WITH IMMUNOCHROMATOGRAPHY AND THIN LAGER CHROMATOGRAPHY (TLC) METHOD. SCIENTIFIC JOURNAL OF FORENSIC MEDICINE, 11(4), 190-194. SID. https://sid.ir/paper/53451/en

Vancouver: Copy

SOLTANINEZHAD K., FARYADI M., AKHGARI M., FAZILATI MOHAMMAD. THE EVALUATION OF PUPIL REFLEXOMETRY METHOD TO THE ADDRESS OF A SCREENING TEST FOR ANALYSIS OF OPIOID MISAPPLICATION AND COMPARISON IT WITH IMMUNOCHROMATOGRAPHY AND THIN LAGER CHROMATOGRAPHY (TLC) METHOD. SCIENTIFIC JOURNAL OF FORENSIC MEDICINE[Internet]. 2006;11(4):190-194. Available from: https://sid.ir/paper/53451/en

IEEE: Copy

K. SOLTANINEZHAD, M. FARYADI, M. AKHGARI, and MOHAMMAD FAZILATI, “THE EVALUATION OF PUPIL REFLEXOMETRY METHOD TO THE ADDRESS OF A SCREENING TEST FOR ANALYSIS OF OPIOID MISAPPLICATION AND COMPARISON IT WITH IMMUNOCHROMATOGRAPHY AND THIN LAGER CHROMATOGRAPHY (TLC) METHOD,” SCIENTIFIC JOURNAL OF FORENSIC MEDICINE, vol. 11, no. 4, pp. 190–194, 2006, [Online]. Available: https://sid.ir/paper/53451/en

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