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Information Journal Paper

Title

THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS

Pages

  139-142

Abstract

 INTRODUCTION: Dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in HEMODIALYSIS patients. This study was designed to investigate the efficacy of oral VITAMIN E supplementation on LIPID PROFILE and oxidative stress in HEMODIALYSIS patients.METHODS: The study group consisted of 26 uremic patients (10 women and 16 men), 16-68 years of age undergoing maintenance HEMODIALYSIS three times a week (12 hours/week), lasting a range of 6-108 months, at Vali-e-Asre Hospital in Birjand (Iran). Total ANTIOXIDANT CAPACITY (TAC), LIPID PEROXIDATION, cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein levels were determined before and after oral VITAMIN E supplementation, 400 mg/d for 90 days.RESULTS: VITAMIN E supplementation caused a significant decrease in ThioBarbituric Acid Reactive Substances (TBARS) level as a marker for LIPID PEROXIDATION (2.97±0.52 vs. 2.55±0.44, P<0.001) and a significant increase in plasma TAC (1252±348 vs. 1398±372, P<0.01). Although there was a decrease in the level of LIPID PROFILE, there were no statistically significant differences in the means of cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein before and after VITAMIN E supplementation among patients.CONCLUSION: Our results indicated that oral VITAMIN E supplementation might be able to modify oxidative stress by an increase in TAC, and a decrease in LIPID PEROXIDATION; that could be considered as a preventive strategy in HEMODIALYSIS patients. 

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    APA: Copy

    MORTAZAVI MOGHADAM, S.GH.R., ZARBAN, A., & REZVANI, MOHAMMAD REZA. (2007). THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS. ARYA ATHEROSCLEROSIS, 3(3), 139-142. SID. https://sid.ir/paper/535207/en

    Vancouver: Copy

    MORTAZAVI MOGHADAM S.GH.R., ZARBAN A., REZVANI MOHAMMAD REZA. THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS. ARYA ATHEROSCLEROSIS[Internet]. 2007;3(3):139-142. Available from: https://sid.ir/paper/535207/en

    IEEE: Copy

    S.GH.R. MORTAZAVI MOGHADAM, A. ZARBAN, and MOHAMMAD REZA REZVANI, “THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS,” ARYA ATHEROSCLEROSIS, vol. 3, no. 3, pp. 139–142, 2007, [Online]. Available: https://sid.ir/paper/535207/en

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