COMPARING TWO DIFFERENT REGIMENS OF TICLOPIDINE FOR PREVENTION OF ACUTE AND SUBACUTE THROMBOSIS AFTER STENT PTCA

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NAMAZI M.H.; SAFI M.; SAADAT H.; VAKILI H.; GHAZNAVI K.; VALAEI NASER

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Journal Paper

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:6 | Issue:3 (23) Page(s): 215-220

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Title

COMPARING TWO DIFFERENT REGIMENS OF TICLOPIDINE FOR PREVENTION OF ACUTE AND SUBACUTE THROMBOSIS AFTER STENT PTCA

Author(s)

Keywords

STENT PTCA

STENT-INDUCED THROMBOSIS

TICLOPIDINE

Abstract

Background: Regarding the widely usage of STENT PTCA and controversies about efficacy and safety of TICLOPIDINE for prevention of thrombosis, the present study had compared two different regimens of TICLOPIDINE after STENT PTCA in patients referring to Shahid Modarres hospital since 1998 till 2000. Materials and methods: 145 individuals with symptomatic coronary artery disease, candidated for STENT PTCA according to the angiographic studies, had entered this clinical trial. Those with acute coronary syndrome including AMI and unstable angina or those who were not received aspirin or TICLOPIDINE 48 hours prior to the operation have been excluded. Patients were randomly distributed in two groups of case and control. Control group was given TICLOPIDINE 500mg/d for 4 weeks after STENT PTCA, whereas, the case group was received TICLOPIDINE at the dosage of 500mg/d for one week followed by 250mg/d for 3 weeks. Efficacy of both regimens was assessed considering the newly progressed chest pain or ST-T changes in ECG and definite angiographic diagnosis of STENT-INDUCED THROMBOSIS. Results: 60 patients were in the control group and the remaining 85 were studied in the case group. Groups were matched according to the following criteria: age, sex, type of lesion, size of vessel, type of target vessel; size, type, number and place of the stent, severity of primary stenosis and initial and final TIMI. No complication was recorded in the case group; however, acute STENT-INDUCED THROMBOSIS was seen in two patients of the control group. These patients had primary stenosis severity of more than 90%, vessel size of less than 3 mm, comptex lesions, and initial TIMI Flow 11. Wiktor stent was used that was 15-20mm. Both patients were male. Conclusion: Minor dosage of TICLOPIDINE (250 mg daily) is as effective as the dosage of 500mg/d for prevention of STENT-INDUCED THROMBOSIS. Further multicentric studies with greater samples are highly recommended. We also suggest a study to determine the side effects of TICLOPIDINE when prescribed at the dosage of 250 mg/d.

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APA: Copy

NAMAZI, M.H., SAFI, M., SAADAT, H., VAKILI, H., GHAZNAVI, K., & VALAEI, NASER. (2001). COMPARING TWO DIFFERENT REGIMENS OF TICLOPIDINE FOR PREVENTION OF ACUTE AND SUBACUTE THROMBOSIS AFTER STENT PTCA. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(3 (23)), 215-220. SID. https://sid.ir/paper/535801/en

Vancouver: Copy

NAMAZI M.H., SAFI M., SAADAT H., VAKILI H., GHAZNAVI K., VALAEI NASER. COMPARING TWO DIFFERENT REGIMENS OF TICLOPIDINE FOR PREVENTION OF ACUTE AND SUBACUTE THROMBOSIS AFTER STENT PTCA. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(3 (23)):215-220. Available from: https://sid.ir/paper/535801/en

IEEE: Copy

M.H. NAMAZI, M. SAFI, H. SAADAT, H. VAKILI, K. GHAZNAVI, and NASER VALAEI, “COMPARING TWO DIFFERENT REGIMENS OF TICLOPIDINE FOR PREVENTION OF ACUTE AND SUBACUTE THROMBOSIS AFTER STENT PTCA,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 3 (23), pp. 215–220, 2001, [Online]. Available: https://sid.ir/paper/535801/en

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