CLOZAPINE EFFECTS ON ELECTROENCEPHALOGRAPHY OF CHRONIC SCHIZOPHRENIC PATIENTS

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ABD ELAHZADEH SH.; VAHIDI J.

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Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2002 | Volume:6 | Issue:SPECIAL ISSUE 6 (26) Page(s): 523-526

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Information Journal Paper

Title

CLOZAPINE EFFECTS ON ELECTROENCEPHALOGRAPHY OF CHRONIC SCHIZOPHRENIC PATIENTS

Author(s)

ABD ELAHZADEH SH. | VAHIDI J. | Issue Writer Certificate

Keywords

REFRACTORY SCHIZOPHRENIA

CLOZAPINE

EEG ABNORMALITIES

Abstract

Background: Refractory schizophrenic patients do not get cured with typical antipsychotic drugs but have showed good treatment response with CLOZAPINE, a novel (atypical) antipsycotic drug. CLOZAPINE major side effects include seizures and agranulocytosis. For finding CLOZAPINE's efficacy in refractory schizophrenic patients and CLOZAPINE-induced EEG abnonnalities, the present study was carried out over the schizophrenic patients admitted sequentially in Imam Hossein hospital, in 1999-2000. Materials and methods: It was a clinical trial. Diagnosis of schizophrenia was based on DSM-IV Criteria for REFRACTORY SCHIZOPHRENIA. Prior to initiation of CLOZAPINE's treatment, EEG was obtained and in case of normal EEG, the candidate was included in our research study. CLOZAPINE was administered at the dosage of 400:1:86.6 mg. Second EEG was obtained 3 week later and reported by a neurologist who was unaware of the study (double-blind). EEG changes were recorded as the presence of slow (theta & delta) waves and were judged with McNemar's statistic. Results: IS refractory schizophrenic patients, including 11 males and 4 females were studied. The mean age of the candidates was 32:1:8.3 years. EEG changes were observed in 12 patients (80%) (p<0.001). Conclusion: CLOZAPINE-induced EEG abnonnalities (slow EEG) are a common side effect, thus, further investigations are strong recommended.

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APA: Copy

ABD ELAHZADEH, SH., & VAHIDI, J.. (2002). CLOZAPINE EFFECTS ON ELECTROENCEPHALOGRAPHY OF CHRONIC SCHIZOPHRENIC PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(SPECIAL ISSUE 6 (26)), 523-526. SID. https://sid.ir/paper/535802/en

Vancouver: Copy

ABD ELAHZADEH SH., VAHIDI J.. CLOZAPINE EFFECTS ON ELECTROENCEPHALOGRAPHY OF CHRONIC SCHIZOPHRENIC PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2002;6(SPECIAL ISSUE 6 (26)):523-526. Available from: https://sid.ir/paper/535802/en

IEEE: Copy

SH. ABD ELAHZADEH, and J. VAHIDI, “CLOZAPINE EFFECTS ON ELECTROENCEPHALOGRAPHY OF CHRONIC SCHIZOPHRENIC PATIENTS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. SPECIAL ISSUE 6 (26), pp. 523–526, 2002, [Online]. Available: https://sid.ir/paper/535802/en

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