LONG-TERM EFFICACY OF TREATMENT WITH LAMIVUDINE IN HBEAG- NEGATIVE PATIENTS WITH DECOMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS B

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MONTAZERI GH.; FARZADI Z.; ABEDIAN SH.; FAZLOLLAHI A.; MALEKZADEH R.

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Journal: GOVARESH JOURNAL Year:2006 | Volume:11 | Issue:3 Page(s): 191-198

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Title

LONG-TERM EFFICACY OF TREATMENT WITH LAMIVUDINE IN HBEAG- NEGATIVE PATIENTS WITH DECOMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS B

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Keywords

CHRONIC HEPATITIS B

DECOMPENSATED CIRRHOSIS

LAMIVUDINE

Abstract

Background: The prognosis of patients with DECOMPENSATED CIRRHOSIS due to hepatitis B is very poor. It has been shown that LAMIVUDINE can improve liver function and delay the need for liver transplantation in HBeAg-positive patients with DECOMPENSATED CIRRHOSIS. However, information regarding long-term use of LAMIVUDINE in HBeAg-negative patients with cirrhosis is limited. The primary objective of this study was to evaluate the long-term efficacy of LAMIVUDINE in HBeAg-negative/HBeAb-positive patients with DECOMPENSATED CIRRHOSIS. Materials and Methods: 54 consecutive HBeAg-negative/HBeAb-positive patients with DECOMPENSATED CIRRHOSIS were enrolled into this study. All patients were treated with 100 mg LAMIVUDINE per day. Significant clinical improvement was defined as a decrease of at least 2 points in Child-Pugh-Turcotte (CPT) score. Repeated-measure one-way analysis of variance was used to evaluate the effect of time interval of LAMIVUDINE treatment on different variables. Kaplan-Meier survival analysis and Mantel-Cox test were used to further analyze the data. Results: The mean±SD age of patients was 50.6±13.2 years. There were 40 male and 14 female patients. The median follow-up was 29 (range: 6-64) months. CPT score, MELD score and blood chemistries changed significantly after 6 months of therapy. The favorable changes were continued up to 2 years. In spite of worsening after 3 years, within subject effects measured by repeated-measure ANOVA, were significant for patients who have received LAMIVUDINE for 4 years or more. Conclusions: Long-term LAMIVUDINE therapy improves liver function in HBeAg-negative/HBeAb-positive patients with DECOMPENSATED CIRRHOSIS.

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APA: Copy

MONTAZERI, GH., FARZADI, Z., ABEDIAN, SH., FAZLOLLAHI, A., & MALEKZADEH, R.. (2006). LONG-TERM EFFICACY OF TREATMENT WITH LAMIVUDINE IN HBEAG- NEGATIVE PATIENTS WITH DECOMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS B. GOVARESH JOURNAL, 11(3), 191-198. SID. https://sid.ir/paper/536033/en

Vancouver: Copy

MONTAZERI GH., FARZADI Z., ABEDIAN SH., FAZLOLLAHI A., MALEKZADEH R.. LONG-TERM EFFICACY OF TREATMENT WITH LAMIVUDINE IN HBEAG- NEGATIVE PATIENTS WITH DECOMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS B. GOVARESH JOURNAL[Internet]. 2006;11(3):191-198. Available from: https://sid.ir/paper/536033/en

IEEE: Copy

GH. MONTAZERI, Z. FARZADI, SH. ABEDIAN, A. FAZLOLLAHI, and R. MALEKZADEH, “LONG-TERM EFFICACY OF TREATMENT WITH LAMIVUDINE IN HBEAG- NEGATIVE PATIENTS WITH DECOMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS B,” GOVARESH JOURNAL, vol. 11, no. 3, pp. 191–198, 2006, [Online]. Available: https://sid.ir/paper/536033/en

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