INVESTIGATION OF THE NUMBER AND AFFINITY OF INSULIN RECEPTORS IN RED BLOOD CELLS OF TYPE 2 DIABETICS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALARI H.; FARZAMI B.; PASALAR P.; ARDESHIR LARIJANI MOHAMMAD BAGHER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2005 | Volume:5 | Issue:1 Page(s): 11-17

Download Full-Text

Persian Verion

View:

1,404

Download:

Cites:

Information Journal Paper

Title

INVESTIGATION OF THE NUMBER AND AFFINITY OF INSULIN RECEPTORS IN RED BLOOD CELLS OF TYPE 2 DIABETICS

Author(s)

SALARI H. | FARZAMI B. | PASALAR P. | ARDESHIR LARIJANI MOHAMMAD BAGHER | Issue Writer Certificate

Keywords

DIABETES TYPE 2Q1

INSULIN RECEPTORSQ4

RED BLOOD CELLQ3

LABELED INSULINQ4

Abstract

Background: The determination of INSULIN RECEPTORS on RBC membrane is a suitable tool for the study of these receptors in diabetes and its related complications. The common methods for the study is the biopsy of fat or muscular tissues, cell culture or a preparation of certain amount of monocytes which is associated with some difficulties. Present study utilizes RBC's for this purpose.Methods: Certain amount of RBCs were exposed to a known amount of LABELED INSULIN and varying concentration of unlabelled Insulin. The competitive effect of Insulin replacement was determined by the measurement of residual receptor radioactivity. This study was carried out in three groups of healthy, poor controlled and good controlled diabetics.Results: There were significant differences between the normal and poor controlled diabetics (P=0.017). In addition differences in receptor binding was obtained between good controlled diabetics and normal which were not significant (P=0.09). All changes were inversely proportional to the HbA1C of specimen. Using Scat chard plots the number of receptors in each group, normal, poor controlled and good controlled were determined to be 1820 (± 72.8), 1026 (±40.4) and 1230 (± 49.2) respectively.Conclusion: Considering the above results, it could be seen that the evaluation of the number of receptors in RBC could be a suitable tool for studying the state of insulin receptor in both physiological and pathological conditions.

Cites

No record.

References

No record.

Cite

APA: Copy

SALARI, H., FARZAMI, B., PASALAR, P., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2005). INVESTIGATION OF THE NUMBER AND AFFINITY OF INSULIN RECEPTORS IN RED BLOOD CELLS OF TYPE 2 DIABETICS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(1), 11-17. SID. https://sid.ir/paper/53897/en

Vancouver: Copy

SALARI H., FARZAMI B., PASALAR P., ARDESHIR LARIJANI MOHAMMAD BAGHER. INVESTIGATION OF THE NUMBER AND AFFINITY OF INSULIN RECEPTORS IN RED BLOOD CELLS OF TYPE 2 DIABETICS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2005;5(1):11-17. Available from: https://sid.ir/paper/53897/en

IEEE: Copy

H. SALARI, B. FARZAMI, P. PASALAR, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “INVESTIGATION OF THE NUMBER AND AFFINITY OF INSULIN RECEPTORS IN RED BLOOD CELLS OF TYPE 2 DIABETICS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 1, pp. 11–17, 2005, [Online]. Available: https://sid.ir/paper/53897/en

Related Journal Papers