THE ACTION PROFILE OF HUMAN INSULIN: AN EUGLYCEMIC CLAMP TEST APPROACH TO COMPARE TWO COMMERCIAL BIOSYNTHETIC INSULIN BRANDS

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ESTEGHAMATI A.A.R.; ABASI M.; YOUSEFIZADEH A.

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Information Journal Paper

Title

THE ACTION PROFILE OF HUMAN INSULIN: AN EUGLYCEMIC CLAMP TEST APPROACH TO COMPARE TWO COMMERCIAL BIOSYNTHETIC INSULIN BRANDS

Author(s)

ESTEGHAMATI A.A.R. | ABASI M. | YOUSEFIZADEH A. | Issue Writer Certificate

Keywords

EUGLYCEMIC CLAMP TECHNIQUEQ4

TIME ACTION PROFILEQ4

BIOAVAILABILITYQ4

HUMAN REGULAR INSULINQ4

Abstract

Background: The aim of this study was to compare TIME ACTION PROFILE of regular human Insulin produced by Exir pharmaceutical Co. and Actrapid® HM produced by Novo Nordisk with EUGLYCEMIC CLAMP TECHNIQUE for the first time in Iran.Methods: Euglycemic glucose clamps were performed with two Insulin brands in a single-center, randomized, double-blind, and crossover study on 6 healthy male volunteers. Glucose disposal kinetics including metabolic clearance rate of glucose (MCRg) and metabolic clearance rate of insulin (MCRi) were determined during a 2-h predetermined intravenous Insulin infusion while blood glucose levels were maintained steady using variable continues intravenous glucose infusions based on method of De Fronzo.Results: There were no differences in glucose kinetics or TIME ACTION PROFILE with respect to glucose infusion rates (688.4 vs. 664.6 mg/kg per 120min), MCRg (0.63±0.19 vs. 0.62±0.25 ml/kg), and MCRi(110 % vs110%) between Exir and Novo Nordisk regular human Insulin preparations. Serum insulin levels increased and serum C-peptide levels decreased with both exogenous Insulin infusions which were statistically the same for both preparations.Conclusion: TIME ACTION PROFILE and BIOAVAILABILITY of regular human insulin produced by Exir Pharmaceutical Corporation is comparable with commonly used Novo Nordisk preparation demonstrated by 2 hour euglycemic clamp study.

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APA: Copy

ESTEGHAMATI, A.A.R., ABASI, M., & YOUSEFIZADEH, A.. (2005). THE ACTION PROFILE OF HUMAN INSULIN: AN EUGLYCEMIC CLAMP TEST APPROACH TO COMPARE TWO COMMERCIAL BIOSYNTHETIC INSULIN BRANDS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(1), 59-65. SID. https://sid.ir/paper/53901/en

Vancouver: Copy

ESTEGHAMATI A.A.R., ABASI M., YOUSEFIZADEH A.. THE ACTION PROFILE OF HUMAN INSULIN: AN EUGLYCEMIC CLAMP TEST APPROACH TO COMPARE TWO COMMERCIAL BIOSYNTHETIC INSULIN BRANDS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2005;5(1):59-65. Available from: https://sid.ir/paper/53901/en

IEEE: Copy

A.A.R. ESTEGHAMATI, M. ABASI, and A. YOUSEFIZADEH, “THE ACTION PROFILE OF HUMAN INSULIN: AN EUGLYCEMIC CLAMP TEST APPROACH TO COMPARE TWO COMMERCIAL BIOSYNTHETIC INSULIN BRANDS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 1, pp. 59–65, 2005, [Online]. Available: https://sid.ir/paper/53901/en

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