COMPARISON OF TWO TYPES OF METFORMIN (ARIA CO. AND MERCK CO) IN TYPE 2 DIABETIC PATIENTS:DOUBLE BLIND RANDOMIZED CLINICAL TRIAL

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TABATABAEI MALAZI A.; HESHMAT RAMIN; HEJAZY MOGADDAM S.A.; EGHBAL TAHERI SA.; SOHEILYKHAH S.; DARVISH ZADEH F.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Iranian Journal of Diabetes and Metabolism Year:2005 | Volume:5 | Issue:1 Page(s): 49-58

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Title

COMPARISON OF TWO TYPES OF METFORMIN (ARIA CO. AND MERCK CO) IN TYPE 2 DIABETIC PATIENTS:DOUBLE BLIND RANDOMIZED CLINICAL TRIAL

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Keywords

TYPE 2 DIABETES MELLITUSQ1

METFORMINQ2

CLINICAL TRIALQ3

SIDE EFFECTSQ3

THERAPEUTIC EFFECTSQ3

Abstract

Background: METFORMIN is usually using for glycemic control in TYPE 2 DIABETES MELLITUS. The drug is the first line for obese patients without renal or liver failure. Different pharmaceutical types of METFORMIN are available. As a CLINICAL TRIAL, we compared effects of Aria METFORMIN (product of Aria pharmaceutical company, Iran) with Merck METFORMIN or Glucophage (product of Merck pharmaceutical company, France), in diabetic patients.Methods: This double blind randomized CLINICAL TRIAL study performed with 60 non- pregnant diabetic patients, in order to comparison of THERAPEUTIC EFFECTS of combination therapy (Glibenclamide + METFORMIN "Aria or Merck") in a 12 weeks period. We evaluated FBS, BS 2hpp, HbA1c, lipid profile, liver function tests, weight, BMI and common or uncommon SIDE EFFECTS.Results: Not only each of two pharmaceutical types of METFORMIN had the same THERAPEUTIC EFFECTS for controlling of glycemia, lipid profile and weight, but also there were not difference between them in SIDE EFFECTS. Distention was the most common SIDE EFFECTS of two types products (33%). There is not significant difference between them in common SIDE EFFECTS. 70% of patients were satisfied with each two kinds of METFORMIN.Conclusion: It seems, in view of beneficial THERAPEUTIC EFFECTS of Aria METFORMIN, low rate of SIDE EFFECTS, and finally low cost, Aria METFORMIN is a good choice.

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APA: Copy

TABATABAEI MALAZI, A., HESHMAT, RAMIN, HEJAZY MOGADDAM, S.A., EGHBAL TAHERI, SA., SOHEILYKHAH, S., DARVISH ZADEH, F., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2005). COMPARISON OF TWO TYPES OF METFORMIN (ARIA CO. AND MERCK CO) IN TYPE 2 DIABETIC PATIENTS:DOUBLE BLIND RANDOMIZED CLINICAL TRIAL. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(1), 49-58. SID. https://sid.ir/paper/53904/en

Vancouver: Copy

TABATABAEI MALAZI A., HESHMAT RAMIN, HEJAZY MOGADDAM S.A., EGHBAL TAHERI SA., SOHEILYKHAH S., DARVISH ZADEH F., ARDESHIR LARIJANI MOHAMMAD BAGHER. COMPARISON OF TWO TYPES OF METFORMIN (ARIA CO. AND MERCK CO) IN TYPE 2 DIABETIC PATIENTS:DOUBLE BLIND RANDOMIZED CLINICAL TRIAL. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2005;5(1):49-58. Available from: https://sid.ir/paper/53904/en

IEEE: Copy

A. TABATABAEI MALAZI, RAMIN HESHMAT, S.A. HEJAZY MOGADDAM, SA. EGHBAL TAHERI, S. SOHEILYKHAH, F. DARVISH ZADEH, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “COMPARISON OF TWO TYPES OF METFORMIN (ARIA CO. AND MERCK CO) IN TYPE 2 DIABETIC PATIENTS:DOUBLE BLIND RANDOMIZED CLINICAL TRIAL,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 1, pp. 49–58, 2005, [Online]. Available: https://sid.ir/paper/53904/en

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