THE INTERACTION EFFECT OF GLIBENCLAMIDE AND AEROBIC TRAINING ON C-PEPTIDE, INSULIN AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS

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SARDAR M.A.; SHAMSIAN S.A.A.; TAGHAVI SEYED MORTEZA

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Journal: Iranian Journal of Diabetes and Metabolism Year:2006 | Volume:6 | Issue:1 Page(s): 91-99

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Title

THE INTERACTION EFFECT OF GLIBENCLAMIDE AND AEROBIC TRAINING ON C-PEPTIDE, INSULIN AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS

Author(s)

SARDAR M.A. | SHAMSIAN S.A.A. | TAGHAVI SEYED MORTEZA | Issue Writer Certificate

Keywords

AEROBIC TRAININGQ2

TYPE 2 DIABETESQ3

GLIBENCLAMIDEQ3

HBA1CQ3

C-PEPTIDEQ3

INSULIN RESISTANCEQ2

Abstract

Background: Combination of physical activity and pharmacotherapy in diabetes may augment the effects of the drug and may allow lower doses of medication that can minimize the side effects The goal of the study was to determine the effectiveness of AEROBIC TRAINING and GLIBENCLAMIDE combination in TYPE 2 DIABETES. Methods: A total of 28 men with TYPE 2 DIABETES were divided to 3 groups randomly: GLIBENCLAMIDE (5 mg daily) only, GLIBENCLAMIDE (5 mg daily) plus AEROBIC TRAINING, GLIBENCLAMIDE (2.5 mg daily) plus AEROBIC TRAINING AEROBIC TRAINING protocol was performed for 12 week, 3 days (session) a week, 45 minutes in a session (ergo cycle program at 60-70 % heart rate reserve) Fasting glucose, HBA1C, fasting insulin, C-PEPTIDE, and INSULIN RESISTANCE were measured at pre, mid and post treatment periods Analysis of Variance test (ANOVA) were used to evaluate data. Results: HBA1C significantly decreased and C-PEPTIDE significantly increased in three groups (P<0.05).There were also no between-group differences for C-PEPTIDE and HBA1C (P>0.05) Fasting insulin concentration did not alter in three groups, however, INSULIN RESISTANCE decreased (no significant) after 12 weeks. Conclusion: In type 2 diabetic patients, GLIBENCLAMIDE treatment alone or combination of AEROBIC TRAINING and GLIBENCLAMIDE treatment, was effective in improving glycemic control in patients with TYPE 2 DIABETES .As a result, in patients with TYPE 2 DIABETES, the addition of AEROBIC TRAINING to Glibencelamide treatment allow lower doses of GLIBENCLAMIDE to be used without impairment in glycemic control.

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APA: Copy

SARDAR, M.A., SHAMSIAN, S.A.A., & TAGHAVI, SEYED MORTEZA. (2006). THE INTERACTION EFFECT OF GLIBENCLAMIDE AND AEROBIC TRAINING ON C-PEPTIDE, INSULIN AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 6(1), 91-99. SID. https://sid.ir/paper/53973/en

Vancouver: Copy

SARDAR M.A., SHAMSIAN S.A.A., TAGHAVI SEYED MORTEZA. THE INTERACTION EFFECT OF GLIBENCLAMIDE AND AEROBIC TRAINING ON C-PEPTIDE, INSULIN AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2006;6(1):91-99. Available from: https://sid.ir/paper/53973/en

IEEE: Copy

M.A. SARDAR, S.A.A. SHAMSIAN, and SEYED MORTEZA TAGHAVI, “THE INTERACTION EFFECT OF GLIBENCLAMIDE AND AEROBIC TRAINING ON C-PEPTIDE, INSULIN AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 6, no. 1, pp. 91–99, 2006, [Online]. Available: https://sid.ir/paper/53973/en

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