THE VALUE OF GLYCOSYLATED HEMOGLOBIN IN SCREENING FOR IMPAIRED GLUCOSE TOLERANCE AND DIABETES MELLITUS

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AMINI MASOUD; HOSSEINPOUR M.; SATTARI G.; HAGHIGHI S.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2002 | Volume:1 | Issue:1 Page(s): 67-72

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Title

THE VALUE OF GLYCOSYLATED HEMOGLOBIN IN SCREENING FOR IMPAIRED GLUCOSE TOLERANCE AND DIABETES MELLITUS

Author(s)

AMINI MASOUD | HOSSEINPOUR M. | SATTARI G. | HAGHIGHI S. | Issue Writer Certificate

Keywords

GLYCOSYLATED HEMOGLOBINQ3

HBALCQ4

DIABETES MELLITUSQ4

IMPAIRED GLUCOSE TOLERANCEQ4

SCREENINGQ3

SENSITIVITYQ3

SPECIFICITYQ3

Abstract

Background: Oral glucose tolerance testing (OGTT) is the gold standard for the diagnosis of DIABETES MELLITUS and IMPAIRED GLUCOSE TOLERANCE (IGT), but is time consuming and difficult to perform. We investigated the value of GLYCOSYLATED HEMOGLOBIN (HbAlc) in SCREENING for DIABETES MELLITUS and IGT. Methods: In a cross-sectional study, we measured the HBALC levels of 497 people referred for OGTT. We calculated the SENSITIVITY and SPECIFICITY of HBALC at 1, 2, 3 and 4 SD above the normal mean. We plotted receiver operating characteristic (ROC) curves after assigning our subjects to the diabetic, IGT, "diabetic+IGT", or normal group, based on WHO criteria for OGTT. Results: HBALC levels (mean±SD) in the four groups were 9.2±l.5, 8.4±1.3, and 7.9±0.8 and 6.8±0.7 percent in the diabetic, diabetic+ IGT, IGT and normal groups, respectively. All differences were statistically significant (p<0.000l). ROC curve analysis showed that HbA1C levels above 7.5% (mean+1 SD) gave the best combination of SENSITIVITY and SPECIFICITY for the detection of diabetes (97.53% and 73.8%), IGT (66.37 and 69.44%), and diabetes+IGT (80.22% and 86.66%). Conclusions: An HBALC level of >7.5% is an optimal cutoff point for diabetes SCREENING programs.

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APA: Copy

AMINI, MASOUD, HOSSEINPOUR, M., SATTARI, G., & HAGHIGHI, S.. (2002). THE VALUE OF GLYCOSYLATED HEMOGLOBIN IN SCREENING FOR IMPAIRED GLUCOSE TOLERANCE AND DIABETES MELLITUS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 1(1), 67-72. SID. https://sid.ir/paper/54024/en

Vancouver: Copy

AMINI MASOUD, HOSSEINPOUR M., SATTARI G., HAGHIGHI S.. THE VALUE OF GLYCOSYLATED HEMOGLOBIN IN SCREENING FOR IMPAIRED GLUCOSE TOLERANCE AND DIABETES MELLITUS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2002;1(1):67-72. Available from: https://sid.ir/paper/54024/en

IEEE: Copy

MASOUD AMINI, M. HOSSEINPOUR, G. SATTARI, and S. HAGHIGHI, “THE VALUE OF GLYCOSYLATED HEMOGLOBIN IN SCREENING FOR IMPAIRED GLUCOSE TOLERANCE AND DIABETES MELLITUS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 1, no. 1, pp. 67–72, 2002, [Online]. Available: https://sid.ir/paper/54024/en

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