RELATIONSHIP BETWEEN LEVELS OF HOMOCYSTEIN IN DIABETIC AND NONDIABETIC PATIENTS WITH CORONARY ARTERY DISEASE

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ZAKERI H.; IZADI J.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2006 | Volume:5 | Issue:4 Page(s): 339-344

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Title

RELATIONSHIP BETWEEN LEVELS OF HOMOCYSTEIN IN DIABETIC AND NONDIABETIC PATIENTS WITH CORONARY ARTERY DISEASE

Author(s)

ZAKERI H. | IZADI J. | Issue Writer Certificate

Keywords

HOMOCYSTEINQ3

DIABETESQ2

CORONARY ARTERY DISEASEQ3

Abstract

Background: Atherosclerosis manifests earlier and more extensive in severity among diabetic patients. It seems HOMOCYSTEIN is one of the accelerating factors in development of atherosclerosis and serum levels HOMOCYSTEIN increase in patients with coronary artery involvement. The aim of this investigation was to compare HOMOCYSTEIN levels between diabetic and non-diabetic patients with CORONARY ARTERY DISEASE (CAD). Methods: As a case-control study via non-randomized sampling method we collected 33 diabetic CAD patient and 34 CAD patient with normal GTT test. All participants were matched in age, sex, family history of atherosclerosis, blood pressure, smoking, the level of triglyceride, total cholesterol, LDL-C and Body Mass Index (BMI). Fasting serum HOMOCYSTEIN was measured via ELISA technique and other selected variables also were assessed via conventional laboratory methods. The quantitative variables between two groups analyzed by student t-test, while the qualitative variables examined by X2. We used Pearson–spearman test for correlation analysis between two groups. Results: 33 diabetic and non-diabetic CAD/MI cases were participated. Among diabetic and non-diabetic subjects, mean age were 59.5±10.5 and 62.5±9.5 respectively. The mean duration of DIABETES was 5.4±4.1 years. Comparison of the mean HOMOCYSTEIN levels between two groups revealed a significant differences, 16.2±4.8 mmol/L in diabetics vs. 10.6±4.8 mmol/L in non-diabetics (P<0.5). Correlation between HOMOCYSTEIN levels and blood glucose, uric acid, triglyceride were r≤0.69, r=0.46 and r=0.51, respectively.Conclusion: Fasting serum HOMOCYSTEIN in diabetic CAD subjects was higher than non-diabetic CAD cases. Our findings may suggest that the increased level of HOMOCYSTEIN is correlated to high prevalence and severity of atherosclerosis among diabetic individuals.

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APA: Copy

ZAKERI, H., & IZADI, J.. (2006). RELATIONSHIP BETWEEN LEVELS OF HOMOCYSTEIN IN DIABETIC AND NONDIABETIC PATIENTS WITH CORONARY ARTERY DISEASE. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(4), 339-344. SID. https://sid.ir/paper/54050/en

Vancouver: Copy

ZAKERI H., IZADI J.. RELATIONSHIP BETWEEN LEVELS OF HOMOCYSTEIN IN DIABETIC AND NONDIABETIC PATIENTS WITH CORONARY ARTERY DISEASE. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2006;5(4):339-344. Available from: https://sid.ir/paper/54050/en

IEEE: Copy

H. ZAKERI, and J. IZADI, “RELATIONSHIP BETWEEN LEVELS OF HOMOCYSTEIN IN DIABETIC AND NONDIABETIC PATIENTS WITH CORONARY ARTERY DISEASE,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 4, pp. 339–344, 2006, [Online]. Available: https://sid.ir/paper/54050/en

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