THE EFFECT OF L – CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ – INDUCED DIABETIC AND NORMAL RATS

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SHARIFI A.M; GHADERPANAHI M.; HOSSEINI MAZHARI S.Z.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2007 | Volume:6 | Issue:3 Page(s): 225-233

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Title

THE EFFECT OF L – CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ – INDUCED DIABETIC AND NORMAL RATS

Author(s)

SHARIFI A.M | GHADERPANAHI M. | HOSSEINI MAZHARI S.Z. | Issue Writer Certificate

Keywords

L-CARNITINEQ3

DIABETESQ2

HYPERTENSIONQ2

NITRIC OXIDEQ3

ANGIOTENSIN CONVERTING ENZYMEQ3

Abstract

Background: Cardiovascular disease including HYPERTENSION is complications of long-standing DIABETES. A few Studies had shown the positive effects of L-CARNITINE on HYPERTENSION. In this study, the possible effects of L-carnitne on NITRIC OXIDE (NO) levels and angiotensin-converting enzyme (ACE) activity in serum as well as systolic blood pressure (SBP) in diabetic and normal rats were studied.Methods: In this study forty rats were used in four groups including non–treated control (C), L-carnitne treated control (CT), diabetic (D) and L-carnitne treated diabetic (DT). DIABETES was induced in rats by injection of stereptozotosin. Both of C & D groups had a free access to food and water and CT & DT groups were received daily dose of L-carnation in drinking water. At the end of 12 weeks SBP, serum NO and ACE activity were measured.Results: Systolic blood pressure was significantly decreased in DT group compared to D group. Serum ACE activity was also significantly decreased in DT group compared to D group and the serum NO levels were significantly increased in DT & CT groups compared to D & C groups respectively.Conclusion: Finally it could be concluded that L-CARNITINE may reduce SBP in diabetic rats via elevation of serum NO levels and reduction of serum ACE activity.

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APA: Copy

SHARIFI, A.M, GHADERPANAHI, M., & HOSSEINI MAZHARI, S.Z.. (2007). THE EFFECT OF L – CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ – INDUCED DIABETIC AND NORMAL RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 6(3), 225-233. SID. https://sid.ir/paper/54066/en

Vancouver: Copy

SHARIFI A.M, GHADERPANAHI M., HOSSEINI MAZHARI S.Z.. THE EFFECT OF L – CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ – INDUCED DIABETIC AND NORMAL RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2007;6(3):225-233. Available from: https://sid.ir/paper/54066/en

IEEE: Copy

A.M SHARIFI, M. GHADERPANAHI, and S.Z. HOSSEINI MAZHARI, “THE EFFECT OF L – CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ – INDUCED DIABETIC AND NORMAL RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 6, no. 3, pp. 225–233, 2007, [Online]. Available: https://sid.ir/paper/54066/en

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