RANDOMISED. DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ANETHUM, NICOTINIC ACID AND CLOFFFIRATE IN PATIENTS WITH ISOLATED HYPERTRIGLYCERIDAEMIA

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MIRZAZADEH AZIM; FOTOUHI A.; ALLAODDINI F.; YAZDANI K.; ARIA ARASH; ASGHARI F.; SHAYANFAR SH.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2002 | Volume:1 | Issue:2 Page(s): 139-148

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Title

RANDOMISED. DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ANETHUM, NICOTINIC ACID AND CLOFFFIRATE IN PATIENTS WITH ISOLATED HYPERTRIGLYCERIDAEMIA

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Keywords

HYPERTRIGLYCERIDAEMIAQ4

ANETHUMQ4

NICOTINIC ACIDQ4

CLOFIBRATEQ3

CLINICAL TRIALQ3

Abstract

Introduction: ANETHUM is an herbal medicine composed of the three plants species ANETHUM, Fumaria and Cichorium, and has been widely marketed and prescribed as lipid-lowering agent in Iran in recent years. No controlled CLINICAL TRIAL of this medicine has so far been carried out, however. We studied the efficacy and short-term side effects of ANETHUM in patients with isolated HYPERTRIGLYCERIDAEMIA. Methods: 151 people (54 men and 97 women) with serum triglyceride >=250 mg/dl and serum cholesterol <240mg/dl were enrolled in this study. Participants were randomly assigned to one of four treatment groups: ANETHUM, NICOTINIC ACID, CLOFIBRATE, and placebo. They were seen at the Doctor Shariati University Hospital lipid clinic once every two weeks. Serum lipid profile was measured at 2 and 4 months after start of therapy. Relevant patient details, including sex, body mass index, mean total cholesterol and high-density lipoprotein, cigarette smoking, previous myocardial infarction, physical activity, and oral contraceptive use were recorded before enrolment. Results: Four months after treatment was started, serum triglyceride had decreased 12.5% in the ANETHUM group and 6.8% in the placebo group (p=0.999). During the same period, serum triglyceride had decreased 48.8% in the NICOTINIC ACID group and 54.4% in the CLOFIBRATE group (p=0.006 wit-It respect to both placebo and ANETHUM). Furthennore, the NICOTINIC ACID group showed a 7.8% decrease in serum total cholesterol (p=0.009 with respect to the other three groups). HDL-C decreased 9.8% in the ANETHUM group, 17.5% in the NICOTINIC ACID group, 8.1% in the CLOFIBRATE group, and 9.1% in the placebo group (p=0.149 between first three groups and placebo). 81.8% of the NICOTINIC ACID, 57.1% of the CLOFIBRATE, 8.0% of the ANETHUM and 30% of the placebo group experienced side effects during the same period. The most common complaints in the ANETHUM were actually non-specific ones. Conclusion: We conclude that ANETHUM does not exert any therapeutic effect on isolated HYPERTRIGLYCERIDAEMIA.

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APA: Copy

MIRZAZADEH, AZIM, FOTOUHI, A., ALLAODDINI, F., YAZDANI, K., ARIA, ARASH, ASGHARI, F., & SHAYANFAR, SH.. (2002). RANDOMISED. DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ANETHUM, NICOTINIC ACID AND CLOFFFIRATE IN PATIENTS WITH ISOLATED HYPERTRIGLYCERIDAEMIA. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 1(2), 139-148. SID. https://sid.ir/paper/54115/en

Vancouver: Copy

MIRZAZADEH AZIM, FOTOUHI A., ALLAODDINI F., YAZDANI K., ARIA ARASH, ASGHARI F., SHAYANFAR SH.. RANDOMISED. DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ANETHUM, NICOTINIC ACID AND CLOFFFIRATE IN PATIENTS WITH ISOLATED HYPERTRIGLYCERIDAEMIA. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2002;1(2):139-148. Available from: https://sid.ir/paper/54115/en

IEEE: Copy

AZIM MIRZAZADEH, A. FOTOUHI, F. ALLAODDINI, K. YAZDANI, ARASH ARIA, F. ASGHARI, and SH. SHAYANFAR, “RANDOMISED. DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ANETHUM, NICOTINIC ACID AND CLOFFFIRATE IN PATIENTS WITH ISOLATED HYPERTRIGLYCERIDAEMIA,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 1, no. 2, pp. 139–148, 2002, [Online]. Available: https://sid.ir/paper/54115/en

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