HUMAN SPERM DNA INSTABILITY

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OZMEN B.; AL HASANI S.

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2008 | Volume:10 | Issue:SUPPLEMENT 1 Page(s): 16-16

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Title

HUMAN SPERM DNA INSTABILITY

Author(s)

OZMEN B. | AL HASANI S.

Keywords

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Abstract

Functions of seminal vesicle, prostate and bilateral testes can be determined by parameters of sperm analysis. However traditional spermiogram and classical morphological sometimes fail in certain prediction of reproductive outcome of infertile men. Nevertheless sperm DNA might comprise many useful clinical parameters and predictors for reproductive outcome. Conversely to loose structure of chromatin in somatic cells, chromatin is tightly compacted in human sperm. Sperm DNA damage caused by factors such as reactive oxygen species, febrile disease, testicular hyperthermia, varicoceles, drugs, chemotherapy, radiation, genital tract infections, environmental causes, genetic deficiencies and hormonal factors. There are several tests such as TUNEL, COMET assays, SCSA verify sperm DNA damage by detecting DNA breaks and decreased ratio of protamine/histone or the susceptibility to denaturation. Increased sperm DNA damage has been shown to be related with poor reproductive outcome. Some of the studies indicated only affected fertilization rates whereas other reported both poor embryo quality, and lower ongoing pregnancy rates. More or less the studies met on some topics that till four cell stage embryonic genome is not activated and resulting in unaffected embryo morphology before this stage. As well today recovery of sperm DNA damage by oocyte after fertilization forming healthy embryonic genome up to several damage degrees has been claimed. Therefore in the future sperm DNA damage seemed to have a severe role in assisted reproduction especially in selection of treatment choice.

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APA: Copy

OZMEN, B., & AL HASANI, S.. (2008). HUMAN SPERM DNA INSTABILITY. CELL JOURNAL (YAKHTEH), 10(SUPPLEMENT 1), 16-16. SID. https://sid.ir/paper/542401/en

Vancouver: Copy

OZMEN B., AL HASANI S.. HUMAN SPERM DNA INSTABILITY. CELL JOURNAL (YAKHTEH)[Internet]. 2008;10(SUPPLEMENT 1):16-16. Available from: https://sid.ir/paper/542401/en

IEEE: Copy

B. OZMEN, and S. AL HASANI, “HUMAN SPERM DNA INSTABILITY,” CELL JOURNAL (YAKHTEH), vol. 10, no. SUPPLEMENT 1, pp. 16–16, 2008, [Online]. Available: https://sid.ir/paper/542401/en

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