THE EFFECT OF P53 PROTEIN OVER-EXPRESSION AND ITS CLINICAL FEATURES ON THE RESPONSE TO PREOPERATIVE CHEMO RADIOTHERAPY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA

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SEYLANIAN TOUSI M.; GHAVAM NASIRI M.R.; GHAFARZADEGAN KAMRAN; FANI PAK DEL A.; SALEK R.; ANVARI K.

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Journal Paper

Paper Information

Journal: Iranian Journal of Pathology Year:2008 | Volume:3 | Issue:1 Page(s): 5-10

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Title

THE EFFECT OF P53 PROTEIN OVER-EXPRESSION AND ITS CLINICAL FEATURES ON THE RESPONSE TO PREOPERATIVE CHEMO RADIOTHERAPY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Author(s)

Keywords

ESOPHAGUS

SQUAMOUS CELL CARCINOMA

COMBINED MODALITY THERAPY

CHEMOTHERAPY

RADIOTHERAPY

TUMOR SUPPRESSOR PROTEIN P53

Abstract

Background and Objective: P53 is a suppressive gene that plays a key role in DNA repair and apoptosis. The purpose of this study was to investigate the effect of P53 protein over-expression and some clinicopathological factors on the esophageal SQUAMOUS CELL CARCINOMA (SCC) response to neoadjuvant chemo RADIOTHERAPY. Patients and Methods: In this retrospective cohort study, 44 patients with localized esophageal SCC undergoing neoadjuvant chemo RADIOTHERAPY (cisplatin + 5FU and 40 Gy in 20 fractions of irradiation) and surgery were evaluated. Pretreatment specimens were immunohistochemically assessed for p53 over-expression and scored according to the frequency of stained cells. The pathologic response in resected specimens was categorized as follows: complete response (CR), no evidence of malignant cell; partial response (PR), small foci of malignant cells and negative lymph nodes and minor response, macroscopic residual tumor or positive lymph nodes. Results: It was found out that p53 protein over-expression exists in 29 cases (65.9%). Following Chemo RADIOTHERAPY, CR and PR were found in 9 (20.5%) and 19 cases (43.2%) respectively. There were also no significant association between tumor response and clinicopathological features such as sex (p=1), age (p=0.82), dysphagia grade (p=0.82) and longitudinal length of the tumor (p=0.59). No significant correlation was found between p53 expression and pathological response to preoperative chemo RADIOTHERAPY (p=0.94).Conclusion: These findings suggest that p53 protein expression is not reliable for predicting the response to neoadjuvant chemo RADIOTHERAPY. There were also no correlations between pathological response to chemo RADIOTHERAPY and clinical features such as age, sex, dysphagia grade and longitudinal diameter of the tumor.

Cites

A CLINICAL TRIAL OF NEOADJUVANT CONCURRENT CHEMORADIOTHERAPY FOLLOWED BY RESECTION FOR ESOPHAGEAL CARCINOMA

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APA: Copy

SEYLANIAN TOUSI, M., GHAVAM NASIRI, M.R., GHAFARZADEGAN, KAMRAN, FANI PAK DEL, A., SALEK, R., & ANVARI, K.. (2008). THE EFFECT OF P53 PROTEIN OVER-EXPRESSION AND ITS CLINICAL FEATURES ON THE RESPONSE TO PREOPERATIVE CHEMO RADIOTHERAPY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP), 3(1), 5-10. SID. https://sid.ir/paper/543793/en

Vancouver: Copy

SEYLANIAN TOUSI M., GHAVAM NASIRI M.R., GHAFARZADEGAN KAMRAN, FANI PAK DEL A., SALEK R., ANVARI K.. THE EFFECT OF P53 PROTEIN OVER-EXPRESSION AND ITS CLINICAL FEATURES ON THE RESPONSE TO PREOPERATIVE CHEMO RADIOTHERAPY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2008;3(1):5-10. Available from: https://sid.ir/paper/543793/en

IEEE: Copy

M. SEYLANIAN TOUSI, M.R. GHAVAM NASIRI, KAMRAN GHAFARZADEGAN, A. FANI PAK DEL, R. SALEK, and K. ANVARI, “THE EFFECT OF P53 PROTEIN OVER-EXPRESSION AND ITS CLINICAL FEATURES ON THE RESPONSE TO PREOPERATIVE CHEMO RADIOTHERAPY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 3, no. 1, pp. 5–10, 2008, [Online]. Available: https://sid.ir/paper/543793/en

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