EVALUATION OF RADIOLABELED STREPTOKINASE FOR THROMBOSIS IMAGING

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JALILIAN AMIR REZA; MIRAZIZI F.; NAZEM H.A.; SHAFEEI K.A.D.; NASERIAN B.; SADEGHPOUR H.

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Paper Information

Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2008 | Volume:16 | Issue:2 (SERIAL NO. 30) Page(s): 34-40

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Title

EVALUATION OF RADIOLABELED STREPTOKINASE FOR THROMBOSIS IMAGING

Author(s)

Keywords

STREPTOKINASE

GALLIUM-67

THROMBOSIS

SPECT

RADIOPHARMACEUTICALS

Abstract

Introduction: Cardiovascular disease is the major cause of morbidity and mortality in developing and developed countries. Rapid diagnosis of the THROMBOSIS can be an essential step in management of thestroke.Methods: In this work a recently developed radiolabeled STREPTOKINASE (STP) tracer was evaluated in an animal thrombotic model using SPECT imaging and biodistribution studies. Locally labeled [67Ga]- STREPTOKINASE was checked by ITLC, HPLC and SDS-PAGE experiments to check the tracer integrity and purity. The biodistribution studies were performed in thrombotic femoral vein of rats using tissue counting and preliminary SPECT studies, respectively (up to 2 h).Results: [67Ga]-STREPTOKINASE prepared with suitable radiochemical purity (HPLC >95%, ITLC >99%) was administered to FeCl3 induced thrombotic rats and the percentage of injected dose per gram of tissue (ID/g%) as well as the SPECT images demonstrated the good specific binding of the tracer in thrombotic clots located in heart and aorta 2 hours post injection.Conclusion: [67Ga]-DTPA-STP can be a suitable probe for imaging of THROMBOSIS in cardiovascular diseases. Ga-68 labeled STP has the potential to be an alternative superior labeled compound due to positron emission properties for PET studies as well as appropriate physical half life.

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APA: Copy

JALILIAN, AMIR REZA, MIRAZIZI, F., NAZEM, H.A., SHAFEEI, K.A.D., NASERIAN, B., & SADEGHPOUR, H.. (2008). EVALUATION OF RADIOLABELED STREPTOKINASE FOR THROMBOSIS IMAGING. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 16(2 (SERIAL NO. 30)), 34-40. SID. https://sid.ir/paper/550866/en

Vancouver: Copy

JALILIAN AMIR REZA, MIRAZIZI F., NAZEM H.A., SHAFEEI K.A.D., NASERIAN B., SADEGHPOUR H.. EVALUATION OF RADIOLABELED STREPTOKINASE FOR THROMBOSIS IMAGING. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2008;16(2 (SERIAL NO. 30)):34-40. Available from: https://sid.ir/paper/550866/en

IEEE: Copy

AMIR REZA JALILIAN, F. MIRAZIZI, H.A. NAZEM, K.A.D. SHAFEEI, B. NASERIAN, and H. SADEGHPOUR, “EVALUATION OF RADIOLABELED STREPTOKINASE FOR THROMBOSIS IMAGING,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 16, no. 2 (SERIAL NO. 30), pp. 34–40, 2008, [Online]. Available: https://sid.ir/paper/550866/en

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