EVALUATION OF ANTIANDROGENIC POTENTIALS OF AQUEOUS EXTRACT OF CHROMOLAENA ODORATUM (L.) K.R. LEAVES IN MALE RATS

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YAKUBU M.T.; AKANJI M.A.; OLADIJI A.T.

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Journal: Cell Journal (Yakhteh) Year:2008 | Volume:10 | Issue:SUPPLEMENT 1 Page(s): 68-68

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Title

EVALUATION OF ANTIANDROGENIC POTENTIALS OF AQUEOUS EXTRACT OF CHROMOLAENA ODORATUM (L.) K.R. LEAVES IN MALE RATS

Author(s)

YAKUBU M.T. | AKANJI M.A. | OLADIJI A.T. | Issue Writer Certificate

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Not Registered.

Abstract

Objective: The antiandrogenic effect of oral administration of aqueous extract of Chromolaena odoratumleaves (250 and 500mg/kg body weight) for 14days in male albino rats was investigated.Materials and Methods: Forty two white albino rats were randomly divided into three groups: A, B and C. Group A which served as the control received 1ml of distilled water (the vehicle) twice daily for 14days while groups B and C were treated the same way like the control except that the animals received 250 and 500mg/kg body weight of the plant extract respectively.Results: Compared with the control, extract administration at 250 and 500mg/kg body weight revealed significant reduction (p<0.05) in testicular body weightratio, acid phosphatase activities, protein, cholesterol, glycogen, sialic acid and testosterone concentrations with a significant increase (p<0.05) in lactate dehydrogenase and γ-glutamyl transferase activities. There was no significant change (p>0.05) in serum concentrations of follicle stimulating and luteinizing hormones. Histological examination revealed disruption in the arrangement of seminiferous tubules with no distinct basement membrane. These changes were accompanied by reduction in the number of spermatozoa.Conclusion: All these results indicated that aqueous extract of Chromolaena odoratum leaves possess antiandrogenic property by interfering with steroidogenesis at the testicular level and this will adversely affect the functional capacity of the testes and the fertility of the animal.

Cites

EFFECT OF PALM POLLEN EXTRACT ON SEXUAL HORMONE LEVELS AND FOLLICLE NUMBERS IN ADULT FEMALE BALB/C MICE

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APA: Copy

YAKUBU, M.T., AKANJI, M.A., & OLADIJI, A.T.. (2008). EVALUATION OF ANTIANDROGENIC POTENTIALS OF AQUEOUS EXTRACT OF CHROMOLAENA ODORATUM (L.) K.R. LEAVES IN MALE RATS. CELL JOURNAL (YAKHTEH), 10(SUPPLEMENT 1), 68-68. SID. https://sid.ir/paper/555263/en

Vancouver: Copy

YAKUBU M.T., AKANJI M.A., OLADIJI A.T.. EVALUATION OF ANTIANDROGENIC POTENTIALS OF AQUEOUS EXTRACT OF CHROMOLAENA ODORATUM (L.) K.R. LEAVES IN MALE RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2008;10(SUPPLEMENT 1):68-68. Available from: https://sid.ir/paper/555263/en

IEEE: Copy

M.T. YAKUBU, M.A. AKANJI, and A.T. OLADIJI, “EVALUATION OF ANTIANDROGENIC POTENTIALS OF AQUEOUS EXTRACT OF CHROMOLAENA ODORATUM (L.) K.R. LEAVES IN MALE RATS,” CELL JOURNAL (YAKHTEH), vol. 10, no. SUPPLEMENT 1, pp. 68–68, 2008, [Online]. Available: https://sid.ir/paper/555263/en

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