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Information Journal Paper

Title

HEPATITIS B VIRUS SURFACE ANTIGEN VARIANTS CLUSTERED WITHIN IMMUNE EPITOPES IN CHRONIC HEPATITIS B CARRIERS FROM HORMOZGAN PROVINCE, SOUTH OF IRAN

Pages

  213-224

Abstract

 Objective (s): The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran.Materials and Methods: A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino acid substitutions were identified compared to the sequences obtained from the database.Results: All strains belonged to genotype D. Overall 77 “mutations” occurred at 45 nucleotide positions, of them, 44 (57.14%) were silent (no amino acid altering) and 33 (42.86%) were missense (amino acid changing). A number of 24 (80%) out of 30 amino acid changes occurred in different immune epitopes within surface protein, of which, 9 (30%) in B cell epitopes in 7 residues (2 occurred in “a” determinant region); 8 (42.1%) in T helper epitopes in 7 residues and 7 (10%) in 4 residues inside CTL epitopes.Conclusion: Hepatitis B virus genome containing mutated immune epitopes no longer could be recognized by specific Tcells of the host immune surveillance and did not enhance anti-HBs production. This could led to the progression of chronicity of hepatitis B virus infection.

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    Cite

    APA: Copy

    NOUROUZI, MAHDI, GHOREYSHI, SEYED ALI, ATAEI, B., YARAN, MAJID, MALEKZADEH, R., ALAVIAN, S.M., JOUDAKI, M.R., GHAMARI, SH., NAMAZI, A.R., RAHIMNIA, RAMIN, KHADIVI, A.A.F., & JAZAYERI, S.M.. (2010). HEPATITIS B VIRUS SURFACE ANTIGEN VARIANTS CLUSTERED WITHIN IMMUNE EPITOPES IN CHRONIC HEPATITIS B CARRIERS FROM HORMOZGAN PROVINCE, SOUTH OF IRAN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 13(4 (47)), 213-224. SID. https://sid.ir/paper/556532/en

    Vancouver: Copy

    NOUROUZI MAHDI, GHOREYSHI SEYED ALI, ATAEI B., YARAN MAJID, MALEKZADEH R., ALAVIAN S.M., JOUDAKI M.R., GHAMARI SH., NAMAZI A.R., RAHIMNIA RAMIN, KHADIVI A.A.F., JAZAYERI S.M.. HEPATITIS B VIRUS SURFACE ANTIGEN VARIANTS CLUSTERED WITHIN IMMUNE EPITOPES IN CHRONIC HEPATITIS B CARRIERS FROM HORMOZGAN PROVINCE, SOUTH OF IRAN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2010;13(4 (47)):213-224. Available from: https://sid.ir/paper/556532/en

    IEEE: Copy

    MAHDI NOUROUZI, SEYED ALI GHOREYSHI, B. ATAEI, MAJID YARAN, R. MALEKZADEH, S.M. ALAVIAN, M.R. JOUDAKI, SH. GHAMARI, A.R. NAMAZI, RAMIN RAHIMNIA, A.A.F. KHADIVI, and S.M. JAZAYERI, “HEPATITIS B VIRUS SURFACE ANTIGEN VARIANTS CLUSTERED WITHIN IMMUNE EPITOPES IN CHRONIC HEPATITIS B CARRIERS FROM HORMOZGAN PROVINCE, SOUTH OF IRAN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 13, no. 4 (47), pp. 213–224, 2010, [Online]. Available: https://sid.ir/paper/556532/en

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