EFFECT OF MELATONIN ON BONE MINERAL DENSITY OF IRRADIATED RATS

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ORBAK Z.; ERTEKIN V.; YILDIRIM M.; ERTEKIN VILDAN; SEVEN B.; KARSLIOGLU I.

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Journal: Cell Journal (Yakhteh) Year:2011 | Volume:12 | Issue:4 (48) Page(s): 459-462

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Title

EFFECT OF MELATONIN ON BONE MINERAL DENSITY OF IRRADIATED RATS

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Keywords

MELATONIN

BONE MINERAL DENSITY

RAT

IRRADIATION

Abstract

Objective: MELATONIN is a powerful endogenous antioxidant and it may play a role in prevention of radiation-induced damage. The aim of this study was to investigate the effect of MELATONIN on BONE MINERAL DENSITY in RATs receiving radiation.Materials and Methods: Sprague Dawley RATs were divided into four groups. Group 1 (control group) received neither MELATONIN nor radiation (control group). Group 2 (Mel group) was administered intraperitoneal injections of 5mg/kg MELATONIN daily for ten days. Group 3 (RT group) and Group 4 were exposed to total cranium radiation of 5 Gy in a single dose by using a cobalt-60 teletherapy unit. In addition to IRRADIATION, group 4 (RT + Mel group) was administered 5mg/kg of MELATONIN intraperitoneally. At the end of the 10th day, the RATs' cranium and vertebrae bone mineral densities (BMDs) were measured.Results: When cranial BMDs were evaluated, statistically more significant BMD increases were seen in the Mel group and the RT + Mel groups than in the control group. No significant difference was seen in the Mel group versus the RT + Mel group; however, there was a significant difference between RT and RT + Mel groups. When vertebral BMDs were evaluated, the only significant difference was found between the control and Mel groups. Conclusion: We think that MELATONIN is a radioprotective agent. However, we would like to emphasize that further studies are needed before clinical trials with MELATONIN are initiated.

Cites

EVALUATION OF RADIO-PROTECTIVE EFFECT OF MELATONIN ON WHOLE BODY IRRADIATION INDUCED LIVER TISSUE DAMAGE

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APA: Copy

ORBAK, Z., ERTEKIN, V., YILDIRIM, M., ERTEKIN, VILDAN, SEVEN, B., & KARSLIOGLU, I.. (2011). EFFECT OF MELATONIN ON BONE MINERAL DENSITY OF IRRADIATED RATS. CELL JOURNAL (YAKHTEH), 12(4 (48)), 459-462. SID. https://sid.ir/paper/556657/en

Vancouver: Copy

ORBAK Z., ERTEKIN V., YILDIRIM M., ERTEKIN VILDAN, SEVEN B., KARSLIOGLU I.. EFFECT OF MELATONIN ON BONE MINERAL DENSITY OF IRRADIATED RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2011;12(4 (48)):459-462. Available from: https://sid.ir/paper/556657/en

IEEE: Copy

Z. ORBAK, V. ERTEKIN, M. YILDIRIM, VILDAN ERTEKIN, B. SEVEN, and I. KARSLIOGLU, “EFFECT OF MELATONIN ON BONE MINERAL DENSITY OF IRRADIATED RATS,” CELL JOURNAL (YAKHTEH), vol. 12, no. 4 (48), pp. 459–462, 2011, [Online]. Available: https://sid.ir/paper/556657/en

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