COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY AND CHROMOGENIC IN SITU HYBRIDIZATION METHOD IN ASSESSMENT OF HER-2 STATUS IN BREAST CANCER

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ENSANI F.; KARGAR MOHAMMAD; DAVANLOU M.; IRVANLOU G.; KHAZAEIPOUR Z.

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Journal: Iranian Journal of Surgery Year:2010 | Volume:17 | Issue:4 Page(s): 0-0

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Title

COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY AND CHROMOGENIC IN SITU HYBRIDIZATION METHOD IN ASSESSMENT OF HER-2 STATUS IN BREAST CANCER

Author(s)

Keywords

BREAST CANCER

EPIDERMAL GROWTH FACTOR RECEPTOR

IMMUNOHISTOCHEMISTRY

CHROMOGENIC IN SITU HYBRIDIZATION

Abstract

Introduction & Objective: The EPIDERMAL GROWTH FACTOR RECEPTOR gene (HER-2) plays an important role in cell transformation and tumorgenesis. The presence of HER-2 gene generally predicts a good response to anthracycline-based agents and therapies that specifically target HER-2 (Herceptin).Materials & Methods: Comparison between IHC and CISH methods for assessment of HER-2 status was performed on 38 women suffering from invasive ductal carcinoma. Data analysis was performed by pair wise grouped statistical method.Results: There was a good correlation between IHC and CISH methods for assessment of HER-2 status in 92.1% of cases (Kappa=0.938, P<0.001).Conclusions: CISH method is recommended as a complementary method in the assessment of HER-2 status in invasive ductal carcinoma of breast of those having weakly positive HER-2.

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APA: Copy

ENSANI, F., KARGAR, MOHAMMAD, DAVANLOU, M., IRVANLOU, G., & KHAZAEIPOUR, Z.. (2010). COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY AND CHROMOGENIC IN SITU HYBRIDIZATION METHOD IN ASSESSMENT OF HER-2 STATUS IN BREAST CANCER. IRANIAN JOURNAL OF SURGERY, 17(4), 0-0. SID. https://sid.ir/paper/557591/en

Vancouver: Copy

ENSANI F., KARGAR MOHAMMAD, DAVANLOU M., IRVANLOU G., KHAZAEIPOUR Z.. COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY AND CHROMOGENIC IN SITU HYBRIDIZATION METHOD IN ASSESSMENT OF HER-2 STATUS IN BREAST CANCER. IRANIAN JOURNAL OF SURGERY[Internet]. 2010;17(4):0-0. Available from: https://sid.ir/paper/557591/en

IEEE: Copy

F. ENSANI, MOHAMMAD KARGAR, M. DAVANLOU, G. IRVANLOU, and Z. KHAZAEIPOUR, “COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY AND CHROMOGENIC IN SITU HYBRIDIZATION METHOD IN ASSESSMENT OF HER-2 STATUS IN BREAST CANCER,” IRANIAN JOURNAL OF SURGERY, vol. 17, no. 4, pp. 0–0, 2010, [Online]. Available: https://sid.ir/paper/557591/en

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