STUDY OF RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR

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SOBHANI MARYAM; IZADI P.; GHAVAMZADEH ARDESHIR; ALI MOGHADAM K.; IRVANI M.; JAHANI M.; MOUSAVI ASAD ELAH; HADI ASHAR N.; NOURI DALOUEI M.R.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2007 | Volume:4 | Issue:3 (15) Page(s): 175-180

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Title

STUDY OF RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR

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Keywords

BONE MARROW TRANSPLANTATION

GENOTYPE

GRAFT VERSUS HOST DISEASE

Abstract

Background and Objectives: GVHD occurs in 20–40% of recipients of HLA-matched sibling donor grafts. A number of studies suggest that polymorphism in cytokine genes influence susceptibility to post-BMT complications. One of the cytokine gene families (IL-1RN) encodes IL-1 receptor antagonist (IL-1Ra), an anti-inflammatory molecule that competes for receptor binding with IL-1a and IL-1b. The overall contribution of IL-1 to the proinflammatory response depends on the balance between these three molecules. In this study, we decided to evaluate the polymorphisms of IL-1Ra gene that might influence the outcome of BMT.Materials and Methods: In this cohort study, patients' (n=175) and donors' (n=175) DNA from a total of 350 human leucocyte antigen (HLA)-identical sibling allogeneic BMTs were analyzed. IL-1Ra gene polymorphism was studied by PCR-VNTR method. PCR products were then visualized by electrophoresis in 2% agarose gel. Then, the correlation between donor and recipient GENOTYPE and GVHD grade for their respective transplant was assessed.Results: The frequency of the aGVHD grades was divided to grade 0 (38.3%), grade I (17.7%), grade II (27.4%), grade III (13.7%), grade IV (2.9%). Correlation between donor and recipient GENOTYPE and GVHD grade for their respective transplant was assessed. We observed no significant correlation between the IL-1Ra polymorphism and incidence of aGVHD, although possession of the allele 2 in the individual GENOTYPE was associated with less severe acute GVHD.Conclusions: The observed allele frequencies were different from those previously reported. None of the polymorphisms showed association with the presence of acute GVHD. However, presence of allele 2 showed association with aGVHD. If the recipient possesed allele 2, the probability of aGVHD was 46% and in the absence of allele 2, it was 62%. Recipient age, donor age, recipient disease particularly thalassemia were the most remarkable risk factors for acute GVHD.

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APA: Copy

SOBHANI, MARYAM, IZADI, P., GHAVAMZADEH, ARDESHIR, ALI MOGHADAM, K., IRVANI, M., JAHANI, M., MOUSAVI, ASAD ELAH, HADI ASHAR, N., & NOURI DALOUEI, M.R.. (2007). STUDY OF RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 4(3 (15)), 175-180. SID. https://sid.ir/paper/558549/en

Vancouver: Copy

SOBHANI MARYAM, IZADI P., GHAVAMZADEH ARDESHIR, ALI MOGHADAM K., IRVANI M., JAHANI M., MOUSAVI ASAD ELAH, HADI ASHAR N., NOURI DALOUEI M.R.. STUDY OF RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2007;4(3 (15)):175-180. Available from: https://sid.ir/paper/558549/en

IEEE: Copy

MARYAM SOBHANI, P. IZADI, ARDESHIR GHAVAMZADEH, K. ALI MOGHADAM, M. IRVANI, M. JAHANI, ASAD ELAH MOUSAVI, N. HADI ASHAR, and M.R. NOURI DALOUEI, “STUDY OF RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 4, no. 3 (15), pp. 175–180, 2007, [Online]. Available: https://sid.ir/paper/558549/en

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