ORAL TOXICITY OF FENITROTHION IN WISTAR RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY

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AFSHAR SIMIN; HEYDARI REZA; FARSHID A.A.

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Journal: RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE" Year:2008 | Volume:35 | Issue:6 Page(s): 37-50

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Title

ORAL TOXICITY OF FENITROTHION IN WISTAR RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY

Author(s)

AFSHAR SIMIN | HEYDARI REZA | FARSHID A.A. | Issue Writer Certificate

Keywords

FENITROTHIONQ3

HISTOPATHOLOGYQ3

CHOLESTEROLQ3

TRIGLYCERIDESQ3

TOTAL PROTEINQ3

Abstract

The present study was undertaken to evaluate subacute toxicity of orally administered FENITROTHION (FNT) in rats based on the biochemical and histological examination. The study was conducted on 8-week old male Wistar rats that distributed into four groups (three experimental groups and one control group), were treated orally with different doses (25, 50, 100 mg/kg BW) of FENITROTHION for 28 consecutive days. After treatment, blood samples were collected for biochemical studies, also liver and kidney samples were taken for histological studies. Results indicated that exposed groups led to significant dose-dependent increase in serum glucose and CHOLESTEROL levels. Serum TOTAL PROTEIN, albumin and TRIGLYCERIDES were decreased not significantly in exposed groups when compared with control. Results showed that the histopathological changes in the liver were mainly represented by parenchymatous degeneration of hepatocytes with mild necrosis, leucocytic infiltration in the portal area, severe congestion and hemorrhage. Marked tubular dilation, hydropic degenerescence in tubular epithelium, moderate congestion and hemorrhage in the cortical and medulla part of the kidney were recorded. Generally the degrees of observed variations were found to be dose dependent.

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APA: Copy

AFSHAR, SIMIN, HEYDARI, REZA, & FARSHID, A.A.. (2008). ORAL TOXICITY OF FENITROTHION IN WISTAR RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY. RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE", 35(6), 37-50. SID. https://sid.ir/paper/55923/en

Vancouver: Copy

AFSHAR SIMIN, HEYDARI REZA, FARSHID A.A.. ORAL TOXICITY OF FENITROTHION IN WISTAR RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY. RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE"[Internet]. 2008;35(6):37-50. Available from: https://sid.ir/paper/55923/en

IEEE: Copy

SIMIN AFSHAR, REZA HEYDARI, and A.A. FARSHID, “ORAL TOXICITY OF FENITROTHION IN WISTAR RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY,” RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE", vol. 35, no. 6, pp. 37–50, 2008, [Online]. Available: https://sid.ir/paper/55923/en

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