RISK FACTORS FOR HEPATITIS C VIRUS AMONG HIGH-RISK POPULATIONS (INTRAVENOUS DRUG ADDICTS AND PATIENTS WITH THALASSEMIA, HEMOPHILIA, HEMODIALYSIS) IN MAZANDARAN

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RAFIEI ALI REZA; HAGHSHENAS MOHAMMAD REZA; DARZYANI AZIZI MAEDEH; TAHERI SEPIDEH; BABAMAHMOUDI FARHANG; MAKHLOUGH ATIYEH; HOSEINI SEYED HAMZEH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:24 | Issue:81 Page(s): 31-42

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Title

RISK FACTORS FOR HEPATITIS C VIRUS AMONG HIGH-RISK POPULATIONS (INTRAVENOUS DRUG ADDICTS AND PATIENTS WITH THALASSEMIA, HEMOPHILIA, HEMODIALYSIS) IN MAZANDARAN

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Keywords

RISK FACTOR

HEPATITIS C

HIGH-RISK GROUP

Abstract

Background and purpose: More than 3% of the world population are infected with HEPATITIS C virus (HCV) and 50-80% of these patients progress to chronic disease. Approximately 50% of chronically infected patients do not respond to treatment. The purpose of this study was to determine the RISK FACTORs for HEPATITIS C virus among high-risk populations (Intravenous drug addicts and patients with Thalassemia, Hemophilia, hemodialysis patients) in Mazandaran.Materials and methods: Totally, 132 patients (34 with Thalassemia, 31 with hemodialysis, 30 with Hemophilia, and 37 with Intravenous drug addiction) were studied. All patients had anti-HCV and were HCV-RNA positive. Demographic data, epidemiological characteristics, clinical findings and laboratory parameters were recorded in questionnaire. Descriptive analysis was used to determine frequency, mean and standard deviation of parameters. Qualitative and quantitative variables were compared by Chi-square test and ANOVA respectively.Results: 132 patients with established chronic infection (mean age, 35.13 ± 11.92) were studied.The major participants were males (68.9% against 31.4%, P=0.001). The frequencies of alchohol consumtion, drug abuse, history of imprisonment and uncontrolled sex were significantly higher in intravenous drug addicts compered to patients with thalassemia, hemophilia, and patients under hemodialysis (p<0.0001). However, no significant differences were observed between the prevalences of coinfection with HIV and/or HBV and also hospitalization history in high risk groups (p=0.43 and p=0.48, respectively) Conclusion: Due to the lack of vaccine for prevention, inadequate medical treatment for HCV infection and according to the role of nosocomial transmission of HCV infection, serious prevention efforts should be performed in society specially health-care centers and blood banks. Since intravenous drug addiction may play an important role in HCV transmission and persistence, it is necessary to perform psychologic and clinical conseling related to importance of RISK FACTORs. Also, development of health insurance especially for vulnerable groups in society is recommended.

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APA: Copy

RAFIEI, ALI REZA, HAGHSHENAS, MOHAMMAD REZA, DARZYANI AZIZI, MAEDEH, TAHERI, SEPIDEH, BABAMAHMOUDI, FARHANG, MAKHLOUGH, ATIYEH, & HOSEINI, SEYED HAMZEH. (2011). RISK FACTORS FOR HEPATITIS C VIRUS AMONG HIGH-RISK POPULATIONS (INTRAVENOUS DRUG ADDICTS AND PATIENTS WITH THALASSEMIA, HEMOPHILIA, HEMODIALYSIS) IN MAZANDARAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(81), 31-42. SID. https://sid.ir/paper/560433/en

Vancouver: Copy

RAFIEI ALI REZA, HAGHSHENAS MOHAMMAD REZA, DARZYANI AZIZI MAEDEH, TAHERI SEPIDEH, BABAMAHMOUDI FARHANG, MAKHLOUGH ATIYEH, HOSEINI SEYED HAMZEH. RISK FACTORS FOR HEPATITIS C VIRUS AMONG HIGH-RISK POPULATIONS (INTRAVENOUS DRUG ADDICTS AND PATIENTS WITH THALASSEMIA, HEMOPHILIA, HEMODIALYSIS) IN MAZANDARAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;24(81):31-42. Available from: https://sid.ir/paper/560433/en

IEEE: Copy

ALI REZA RAFIEI, MOHAMMAD REZA HAGHSHENAS, MAEDEH DARZYANI AZIZI, SEPIDEH TAHERI, FARHANG BABAMAHMOUDI, ATIYEH MAKHLOUGH, and SEYED HAMZEH HOSEINI, “RISK FACTORS FOR HEPATITIS C VIRUS AMONG HIGH-RISK POPULATIONS (INTRAVENOUS DRUG ADDICTS AND PATIENTS WITH THALASSEMIA, HEMOPHILIA, HEMODIALYSIS) IN MAZANDARAN,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 81, pp. 31–42, 2011, [Online]. Available: https://sid.ir/paper/560433/en

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