CORRELATION BETWEEN SOLUBLE VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTOR 1 WITH RESPONSE TO CHEMOTHERAPY IN ACUTE LEUKEMIA IN CHILDREN

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MEHRAZMA M.; ARJMANDI RAFSANJANI KHADIJEH; TORKAMANIPOUR B.

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Journal: Iranian Journal of Pathology Year:2008 | Volume:3 | Issue:4 Page(s): 179-182

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Title

CORRELATION BETWEEN SOLUBLE VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTOR 1 WITH RESPONSE TO CHEMOTHERAPY IN ACUTE LEUKEMIA IN CHILDREN

Author(s)

MEHRAZMA M. | ARJMANDI RAFSANJANI KHADIJEH | TORKAMANIPOUR B. | Issue Writer Certificate

Keywords

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1

LEUKEMIA

CHILD

VASCULAR ENDOTHELIAL GROWTH FACTOR A

Abstract

Background and Objective: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and R2) are major regulators of angiogenesis. This study was designed to assess serum levels of VEGF and VEGF-R1 and their prognostic significance in newly diagnosed CHILDhood acute LEUKEMIA.Materials and Methods: For this purpose, VEGF and VEGF-R1 were determined using enzyme linked immuno-sorbant assay (ELISA) in samples obtained before treatment. Demographic data were recorded. Bone marrow blast percentage was counted on diagnosis and 2 weeks after induction therapy. A p value less than 0.05 considered significant.Results: Fifty-three CHILDren (22 boys and 31 girls) with newly diagnosed acute LEUKEMIA were enrolled in the study. Most cases (56.6%) were pre B cell ALL. Mean value of VEFG-A in good responders was 55.13 ± 24.96 pg/ml and in poor responders it was 94.46 ± 15.75 (p<0.0001). Mean valve of VEGF-R1 in good and poor responders was 0.132 ± 0.0653 and 0.1665 ± 0.0857 pg/ml respectively (p>0.05). Using ROC curve, we found out a cut-off point of 76 pg/ml to discriminate poor response to chemotherapy.Conclusion: Soluble VEGF-A is an independent factor for response to therapy in CHILDhood LEUKEMIA and leukemic patients with sVEGF-A level over 76 pg/ml will have poor response to treatment.

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APA: Copy

MEHRAZMA, M., ARJMANDI RAFSANJANI, KHADIJEH, & TORKAMANIPOUR, B.. (2008). CORRELATION BETWEEN SOLUBLE VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTOR 1 WITH RESPONSE TO CHEMOTHERAPY IN ACUTE LEUKEMIA IN CHILDREN. IRANIAN JOURNAL OF PATHOLOGY (IJP), 3(4), 179-182. SID. https://sid.ir/paper/563472/en

Vancouver: Copy

MEHRAZMA M., ARJMANDI RAFSANJANI KHADIJEH, TORKAMANIPOUR B.. CORRELATION BETWEEN SOLUBLE VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTOR 1 WITH RESPONSE TO CHEMOTHERAPY IN ACUTE LEUKEMIA IN CHILDREN. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2008;3(4):179-182. Available from: https://sid.ir/paper/563472/en

IEEE: Copy

M. MEHRAZMA, KHADIJEH ARJMANDI RAFSANJANI, and B. TORKAMANIPOUR, “CORRELATION BETWEEN SOLUBLE VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTOR 1 WITH RESPONSE TO CHEMOTHERAPY IN ACUTE LEUKEMIA IN CHILDREN,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 3, no. 4, pp. 179–182, 2008, [Online]. Available: https://sid.ir/paper/563472/en

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