ENDOTHELIUM-DEPENDENT EFFECT OF AMARANTHUS CAUDATUS FEEDING ON CONTRACTILE PROPERTIES OF THORACIC AORTA FROM DIABETIC RATS

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ROGHANI MEHRDAD; BALUCHNEJADMOJARAD TOURANDOKHT; ROGHANI DEHKORDI F.

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Journal: Koomesh Year:2011 | Volume:12 | Issue:4 (40) Page(s): 440-448

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Title

ENDOTHELIUM-DEPENDENT EFFECT OF AMARANTHUS CAUDATUS FEEDING ON CONTRACTILE PROPERTIES OF THORACIC AORTA FROM DIABETIC RATS

Author(s)

ROGHANI MEHRDAD | BALUCHNEJADMOJARAD TOURANDOKHT | ROGHANI DEHKORDI F. | Issue Writer Certificate

Keywords

MARANTHUS CAUDATUS

DIABETES MELLITUS

ENDOTHELIUM

AORTA

THORACIC

RATS

Abstract

Introduction: DIABETES MELLITUS is accompanied with higher incidence of cardiovascular disorders. There is some evidence of antidiabetic and vascular function-improving potential of AMARANTHUS CAUDATUS (AC). ENDOTHELIUM-dependent effects of oral administration of AC for 8 weeks on contractile and relaxatory response of THORACIC AORTA from diabetic RATS were investigated.Materials and Methods: Wistar RATS were divided into control, AC-treated control, diabetic, ACtreated diabetic, and glibenclamide-treated diabetic groups. For induction of type 1 diabetes, streptozotocin at a dose of 60 mg/kg (i.p) was injected. Treated groups received AC-mixed pelleted food at a weight ratio of 6.25%. Body weight and serum glucose level was measured before the study and after 4 and 8 weeks. At the end of study, contractile reactivity of THORACIC aortic rings to KCl and phenylephrine and relaxatory response to acetylcholine and sodium nitroprusside was determined using isolated tissue setup.Results: Serum glucose level significantly decreased in AS-treated diabetic group (P<0.05) versus untreated diabetics. In addition, ENDOTHELIUM-intact AC-treated diabetic group showed a significantly lower contraction to KCl and phenylephrine (P<0.01) as compared to diabetic group and ENDOTHELIUM removal abolished this response. Meanwhile, relaxation response of ENDOTHELIUM-intact rings to acetylcholine was significantly higher in AC-treated diabetic group as compared to diabetics (p<0.01). In addition, there were no significant changes amongst the groups regarding relaxatory response to sodium nitroprusside.Conclusion: Chronic oral administration of AC through affecting endothelial-related agents could decrease contractile response and enhance relaxatory response in aortic tissue of diabetic rat and this may be beneficial in prevention of long-term vascular complications of diabetes.

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APA: Copy

ROGHANI, MEHRDAD, BALUCHNEJADMOJARAD, TOURANDOKHT, & ROGHANI DEHKORDI, F.. (2011). ENDOTHELIUM-DEPENDENT EFFECT OF AMARANTHUS CAUDATUS FEEDING ON CONTRACTILE PROPERTIES OF THORACIC AORTA FROM DIABETIC RATS. KOOMESH, 12(4 (40)), 440-448. SID. https://sid.ir/paper/564127/en

Vancouver: Copy

ROGHANI MEHRDAD, BALUCHNEJADMOJARAD TOURANDOKHT, ROGHANI DEHKORDI F.. ENDOTHELIUM-DEPENDENT EFFECT OF AMARANTHUS CAUDATUS FEEDING ON CONTRACTILE PROPERTIES OF THORACIC AORTA FROM DIABETIC RATS. KOOMESH[Internet]. 2011;12(4 (40)):440-448. Available from: https://sid.ir/paper/564127/en

IEEE: Copy

MEHRDAD ROGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, and F. ROGHANI DEHKORDI, “ENDOTHELIUM-DEPENDENT EFFECT OF AMARANTHUS CAUDATUS FEEDING ON CONTRACTILE PROPERTIES OF THORACIC AORTA FROM DIABETIC RATS,” KOOMESH, vol. 12, no. 4 (40), pp. 440–448, 2011, [Online]. Available: https://sid.ir/paper/564127/en

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