مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ROLE OF CHROMOSOME 17 ANEUSOMY AS A PROGNOSTIC PARAMETER IN SOME IRANIAN WOMEN WITH SPORADIC BREAST CANCER USING INTERPHASE FISH TECHNIQUE

Pages

  65-71

Abstract

 Background and Objectives: BREAST CANCER is the most common cancer amongst IRANian women and worldwide. Unfortunately, the current clinical and histological criteria can only help 60% of women with BREAST CANCER in diagnosis and long-term treatment. Therefore, genetic markers can play an important role in improving the diagnosis and PROGNOSIS of BREAST CANCER patients. The aim of this retrospective study was to investigate the role of CHROMOSOME 17 copy number assessed by INTERPHASE Fluorescence in Situ Hybridization (FISH), as the genetic prognostic parameter.Materials and Methods: Thirty IRANian women, aged 31 to 65 years with sporadic primary breast carcinoma were studied. Chromosome copy number was evaluated in relation to established clinicopathological parameters, the immunohistochemical markers of ER, PR, P53, age and the duration and status of survival in the patients. FISH, using centromeric probe for CHROMOSOME 17 was applied to INTERPHASE cells prepared from paraffin embedded tumor sections. More than 3000 cells for CHROMOSOME 17 were assessed. Data were analyzed with programs in SPSS 11.5.Results: Aneusomy for CHROMOSOME 17 was present in all 30 patients to different levels. The total abnormality rate for CHROMOSOME 17 was 57.03%, in which hypodiploidy was more frequent than hyperdiploidy (2.5 folds). Significant correlation was observed between CHROMOSOME 17 aneusomy rate and the stage of BREAST CANCER (P<0.05).Conclusion: CHROMOSOME 17 hypodiploidy alongside other clinical and pathological parameters may be considered as useful prognostic markers in sporadic carcinoma of breast.

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    Cite

    APA: Copy

    ATAEI KACHOUEI, M., KEYHANI, E., KARBASIAN, H.R., KADIVAR, MARYAM, & BEHJATI, F.. (2010). ROLE OF CHROMOSOME 17 ANEUSOMY AS A PROGNOSTIC PARAMETER IN SOME IRANIAN WOMEN WITH SPORADIC BREAST CANCER USING INTERPHASE FISH TECHNIQUE. IRANIAN JOURNAL OF PATHOLOGY (IJP), 5(2), 65-71. SID. https://sid.ir/paper/564265/en

    Vancouver: Copy

    ATAEI KACHOUEI M., KEYHANI E., KARBASIAN H.R., KADIVAR MARYAM, BEHJATI F.. ROLE OF CHROMOSOME 17 ANEUSOMY AS A PROGNOSTIC PARAMETER IN SOME IRANIAN WOMEN WITH SPORADIC BREAST CANCER USING INTERPHASE FISH TECHNIQUE. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2010;5(2):65-71. Available from: https://sid.ir/paper/564265/en

    IEEE: Copy

    M. ATAEI KACHOUEI, E. KEYHANI, H.R. KARBASIAN, MARYAM KADIVAR, and F. BEHJATI, “ROLE OF CHROMOSOME 17 ANEUSOMY AS A PROGNOSTIC PARAMETER IN SOME IRANIAN WOMEN WITH SPORADIC BREAST CANCER USING INTERPHASE FISH TECHNIQUE,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 5, no. 2, pp. 65–71, 2010, [Online]. Available: https://sid.ir/paper/564265/en

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