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Information Journal Paper

Title

A SURVEY ON THE PRESENCE OF MALASSEZIA IN ACNE LESIONS IN PATIENTS REFERRED TO DERMATOLOGY CLINIC OF BOOALI HOSPITAL FROM SARI AND SUSCEPTIBILITY OF ISOLATED SPECIES TO KETOCONAZOLE‚ MICONAZOLE AND CLOTRIMAZOLE

Pages

  10-19

Abstract

 Background and purpose: MALASSEZIA is one of the etiologic agents of skin disorders such as ACNE and opportunistic pathogen for invasive infections. As no published evidence was found on the distribution of MALASSEZIA in ACNE lesion in Mazandaran province, the present study was carried out to determine the prevalence of MALASSEZIA in ACNE lesions in patients referred to dermatology clinic of Booali hospital in Sari city and to evaluate the susceptibility of isolated species to ketoconazole (KTZ‚ miconazole (MIZ) and clotrimazole (CLZ).Materials and methods: In the present study, 122 patients (66 female and 56 male) were recruited. Samples collected from inside of ACNE mounted by KOH+CFW for microscopic examination.Samples were also cultured using Leeming-Notman medium. The isolated species were identified by their morphologic and physiologic characteristics and confirmed by molecular method. Susceptibility to KTZ‚ CLZ and MIZ were done by Broth microdilution method. Minimal Inhibitory Concentration (MIC) and Minimal Fungicidal Concentration (MFC) determined for each drug.Results: In total, 60 cases (49.2%) were positive for yeast cells in direct microscopic examination.Yeast like fungi growth was positive in 23 samples. MALASSEZIA furfur was obtained in 3 cases (2.5%). Candida species were identified in other cases. The MIC ranges were 0.03-2 mg/ml, 4-16 mg/ml and 2-16 mg/ml for KTZ‚ CLZ and MIZ, respectively. The MFC ranges were 0.03-2 mg/ml, 8-16 mg ml and 4-16 mg/ml for KTZ‚ CLZ and MIZ, respectively.Conclusion: As to considerable number of cases were positive for Candida species in ACNE lesions in the present study, the precise differential diagnosis based on culture of samples is emphasized. The results demonstrated that KTZ is the most effective imidazole against MALASSEZIA furfur isolates.

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    APA: Copy

    KALARESTAGHI, ALI REZA, HAJHEYDARI, ZOHREH, HEDAYATI, MOHAMMAD TAGHI, & SHOKOHI, TAHEREH. (2011). A SURVEY ON THE PRESENCE OF MALASSEZIA IN ACNE LESIONS IN PATIENTS REFERRED TO DERMATOLOGY CLINIC OF BOOALI HOSPITAL FROM SARI AND SUSCEPTIBILITY OF ISOLATED SPECIES TO KETOCONAZOLE‚ MICONAZOLE AND CLOTRIMAZOLE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(81), 10-19. SID. https://sid.ir/paper/564587/en

    Vancouver: Copy

    KALARESTAGHI ALI REZA, HAJHEYDARI ZOHREH, HEDAYATI MOHAMMAD TAGHI, SHOKOHI TAHEREH. A SURVEY ON THE PRESENCE OF MALASSEZIA IN ACNE LESIONS IN PATIENTS REFERRED TO DERMATOLOGY CLINIC OF BOOALI HOSPITAL FROM SARI AND SUSCEPTIBILITY OF ISOLATED SPECIES TO KETOCONAZOLE‚ MICONAZOLE AND CLOTRIMAZOLE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;24(81):10-19. Available from: https://sid.ir/paper/564587/en

    IEEE: Copy

    ALI REZA KALARESTAGHI, ZOHREH HAJHEYDARI, MOHAMMAD TAGHI HEDAYATI, and TAHEREH SHOKOHI, “A SURVEY ON THE PRESENCE OF MALASSEZIA IN ACNE LESIONS IN PATIENTS REFERRED TO DERMATOLOGY CLINIC OF BOOALI HOSPITAL FROM SARI AND SUSCEPTIBILITY OF ISOLATED SPECIES TO KETOCONAZOLE‚ MICONAZOLE AND CLOTRIMAZOLE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 81, pp. 10–19, 2011, [Online]. Available: https://sid.ir/paper/564587/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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