TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH MAJOR β-THALASSEMIA

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BAZVAND FATEMEH; SHAMS SEDIGHEH; BORJI ESFAHANI MAHTAB; KOOCHAKZADEH LILI; MONAJEMZADEH MARYAM; HAGHI ASHTIANI MOHAMMAD TAGHI; REZAEI NIMA

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Journal: Iranian Journal of Pediatrics Year:2011 | Volume:21 | Issue:2 Page(s): 159-165

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Title

TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH MAJOR β-THALASSEMIA

Author(s)

Keywords

β-THALASSEMIA MAJOR

OXIDATIVE STRESS

ANTIOXIDANTS

FERRITIN

URIC ACID

Abstract

Objective: Beta-thalassemia major is an autosomal recessive disease causing severe and hemolytic anemia, which begins about 2-6 months after birth. Iron overload, which arises from recurrent transfusion and ineffective erythropoiesis, can enhance OXIDATIVE STRESS in thalassemic patients.The aim of this study was to evaluate the serum total antioxidant capacity of patients with s-Thalassemia major.Methods: Sixty six Iranian patients with b-thalassemia major and 66 age-gender matched controls were evaluated for serum total antioxidant status (TAS), URIC ACID (UA), bilirubin and albumin. In addition, serum FERRITIN and transaminases were recorded in these subjects.Findings: Significant increases of TAS, UA, and bilirubin were observed in the patient group, compared with the control group (P<0.01). Mean TAS and bilirubin in male patients was higher than in females (P=0.005 and P=0.008, respectively). There was also direct correlation between TAS and albumin (P<0.001), bilirubin (P<0.001) and UA (P=0.002).Conclusion: Endogenous ANTIOXIDANTS such as FERRITIN, UA and bilirubin can result in increased level of TAS in the patients with Beta-thalassemia major. Compensatory excess of TAS to OXIDATIVE STRESS could also be the reason for difference between our findings and previous studies.

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APA: Copy

BAZVAND, FATEMEH, SHAMS, SEDIGHEH, BORJI ESFAHANI, MAHTAB, KOOCHAKZADEH, LILI, MONAJEMZADEH, MARYAM, HAGHI ASHTIANI, MOHAMMAD TAGHI, & REZAEI, NIMA. (2011). TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH MAJOR β-THALASSEMIA. IRANIAN JOURNAL OF PEDIATRICS, 21(2), 159-165. SID. https://sid.ir/paper/565679/en

Vancouver: Copy

BAZVAND FATEMEH, SHAMS SEDIGHEH, BORJI ESFAHANI MAHTAB, KOOCHAKZADEH LILI, MONAJEMZADEH MARYAM, HAGHI ASHTIANI MOHAMMAD TAGHI, REZAEI NIMA. TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH MAJOR β-THALASSEMIA. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2011;21(2):159-165. Available from: https://sid.ir/paper/565679/en

IEEE: Copy

FATEMEH BAZVAND, SEDIGHEH SHAMS, MAHTAB BORJI ESFAHANI, LILI KOOCHAKZADEH, MARYAM MONAJEMZADEH, MOHAMMAD TAGHI HAGHI ASHTIANI, and NIMA REZAEI, “TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH MAJOR β-THALASSEMIA,” IRANIAN JOURNAL OF PEDIATRICS, vol. 21, no. 2, pp. 159–165, 2011, [Online]. Available: https://sid.ir/paper/565679/en

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