FREEZE-DRIED COLD KIT FOR PREPARATION 
OF 99MTC-CIPROFLOXACIN AS AN INFECTION IMAGING AGENT

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MIRSHOJAEI SEYEDEH FATEMEH; ERFANI MOSTAFA; SADAT EBRAHIMI SEYED ESMAEIL; TALEBI MOHAMMAD HOSSEIN; HAJ HASSAN ABBASI FARHAD

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2010 | Volume:18 | Issue:2 (SERIAL NUMBER 34) Page(s): 45-51

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Information Journal Paper

Title

FREEZE-DRIED COLD KIT FOR PREPARATION OF 99MTC-CIPROFLOXACIN AS AN INFECTION IMAGING AGENT

Author(s)

Keywords

SANS-SERIF"> 99M

SANS-SERIF">TC- CIPROFLOXACIN

INFECTION IMAGING

KIT PREPARATION

Abstract

Introduction: Radiolabeled antibiotics are being used for the specific diagnosis of infection by exploiting their specific binding properties to the bacterial components, thereby making it possible to differentiate infection from sterile lesions. The aim of this work was to prepare and evaluate a freeze-dried kit of ciprofloxacin designed for the labeling with 99mTc.Methods: Factors like amount of reducing agent and optimum pH were investigated to make the ciprofloxacin kit. The kit was reconstituted with 99mTc at room temperature and the radiochemical purity was evaluated by ITLC method. Stability and protein binding in human serum followed by in vitro binding to bacteria were assessed. Biodistribution of labeled kit in staphylococcus aureus infected rats muscles were studied using ex vivo counting and scintigraphy.Results: Labeling yield of >90% was obtained corresponding to a specific activity of 178 GBq/mmol. The stability of radiolabeled kit in human serum was 84.2% after 1 hour post incubation. In-vitro studies showed 75 % of radioactivity was bound to bacteria. After injection into mice clearance from the circulation occurred mainly by biliary-renal clearance and site of infection was rapidly detected within 30 min. Target to non-target muscle ratio was 3.23 ± 0.05 % at 30 min post injection.Conclusion: 99mTc-ciprofloxacin showed favorable radiochemical and biological characteristics which permitted detection of the infection with optimal visualization.

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APA: Copy

MIRSHOJAEI, SEYEDEH FATEMEH, ERFANI, MOSTAFA, SADAT EBRAHIMI, SEYED ESMAEIL, TALEBI, MOHAMMAD HOSSEIN, & HAJ HASSAN ABBASI, FARHAD. (2010). FREEZE-DRIED COLD KIT FOR PREPARATION OF ^99MTC-CIPROFLOXACIN AS AN INFECTION IMAGING AGENT. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(2 (SERIAL NUMBER 34)), 45-51. SID. https://sid.ir/paper/565931/en

Vancouver: Copy

MIRSHOJAEI SEYEDEH FATEMEH, ERFANI MOSTAFA, SADAT EBRAHIMI SEYED ESMAEIL, TALEBI MOHAMMAD HOSSEIN, HAJ HASSAN ABBASI FARHAD. FREEZE-DRIED COLD KIT FOR PREPARATION OF ^99MTC-CIPROFLOXACIN AS AN INFECTION IMAGING AGENT. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(2 (SERIAL NUMBER 34)):45-51. Available from: https://sid.ir/paper/565931/en

IEEE: Copy

SEYEDEH FATEMEH MIRSHOJAEI, MOSTAFA ERFANI, SEYED ESMAEIL SADAT EBRAHIMI, MOHAMMAD HOSSEIN TALEBI, and FARHAD HAJ HASSAN ABBASI, “FREEZE-DRIED COLD KIT FOR PREPARATION OF ^99MTC-CIPROFLOXACIN AS AN INFECTION IMAGING AGENT,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. 2 (SERIAL NUMBER 34), pp. 45–51, 2010, [Online]. Available: https://sid.ir/paper/565931/en

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