مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

456
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

349
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EXTRACT OF AZADIRACHTA INDICA (NEEM) LEAF INDUCES APOPTOSIS IN 4T1 BREAST CANCER BALB/C MICE

Pages

  107-116

Abstract

 Objective: Azadirachta indica (Neem) has been used traditionally for many centuries.Some impressive therapeutic qualities have been discovered. However, the therapeutic effect of NEEM leaf extract in 4T1 BREAST CANCER has not been documented. The purpose of the present study is to investigate the therapeutic effect of ethanolic NEEM leaf extract in anin vivo 4T1 BREAST CANCER model in mice.Materials and Methods: A total of 84 female BALB/c mice were divided randomly into 7 groups (3 non-cancerous groups and 4 cancerous groups) consisting of 12 mice per group. The 3 non-cancerous groups were normal mice treated with 0.5% of Tween 20 in phosphate buffer saline (PBS) (NC), 250 mg/kg NEEM (N250) or 500 mg/kg NEEM (N500).The 4 cancerous groups were; cancer controls treated with 0.5% of Tween 20 in PBS (CC), and cancerous mice treated with 0.5μg/mL tamoxifen citrate (CT), 250 mg/kg NEEM leaf extract (CN 250) or 500 mg/kg NEEM leaf extract (CN 500). Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were used to evaluate APOPTOSIS (cell death) in the BREAST CANCER tissues. SPSS software, version 14 was used for statistical analysis. Statistical significance was defined as p<0.05. Non parametric analysis of variance (ANOVA) was performed with the Kruskal Wallis test for the TUNEL assays.Parametric data among the groups was compared using ANOVA.Results: TUNEL assays showed that the CN 250 and CN 500 groups had a higher incidence of APOPTOSIS compared with the cancer controls.Conclusion: The findings showed that NEEM leaf extract induces APOPTOSIS in 4T1 BREAST CANCER BALB/c mice.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    OTHMAN, FAUZIAH, MOTALLEB, GHOLAMREZA, LAM TSUEY PENG, SALLY, RAHMAT, ASMAH, FAKURAZI, SHARIDA, & CHONG, PEI PEI. (2011). EXTRACT OF AZADIRACHTA INDICA (NEEM) LEAF INDUCES APOPTOSIS IN 4T1 BREAST CANCER BALB/C MICE. CELL JOURNAL (YAKHTEH), 13(2 (50)), 107-116. SID. https://sid.ir/paper/567010/en

    Vancouver: Copy

    OTHMAN FAUZIAH, MOTALLEB GHOLAMREZA, LAM TSUEY PENG SALLY, RAHMAT ASMAH, FAKURAZI SHARIDA, CHONG PEI PEI. EXTRACT OF AZADIRACHTA INDICA (NEEM) LEAF INDUCES APOPTOSIS IN 4T1 BREAST CANCER BALB/C MICE. CELL JOURNAL (YAKHTEH)[Internet]. 2011;13(2 (50)):107-116. Available from: https://sid.ir/paper/567010/en

    IEEE: Copy

    FAUZIAH OTHMAN, GHOLAMREZA MOTALLEB, SALLY LAM TSUEY PENG, ASMAH RAHMAT, SHARIDA FAKURAZI, and PEI PEI CHONG, “EXTRACT OF AZADIRACHTA INDICA (NEEM) LEAF INDUCES APOPTOSIS IN 4T1 BREAST CANCER BALB/C MICE,” CELL JOURNAL (YAKHTEH), vol. 13, no. 2 (50), pp. 107–116, 2011, [Online]. Available: https://sid.ir/paper/567010/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button