EFFECTS OF COMBINED SONODYNAMIC AND PHOTODYNAMIC THERAPIES ON A COLON CARCINOMA TUMOR MODEL

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BAKHSHIZADEH MARYAM; SAZGARNIA AMENEH; RAJABI OMID; KHOOEI ALI REZA; ESMAILY HABIBOLLAH

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Journal: Iranian Journal of Basic Medical Sciences Year:2011 | Volume:14 | Issue:3 (50) Page(s): 205-212

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Title

EFFECTS OF COMBINED SONODYNAMIC AND PHOTODYNAMIC THERAPIES ON A COLON CARCINOMA TUMOR MODEL

Author(s)

Keywords

CARCINOMA

COLON

LIPOSOME

PHOTODYNAMIC THERAPY

SONODYNAMIC THERAPY

ZN (II)-PHTHALOCYANINE

Abstract

Objective(s): Although PHOTODYNAMIC THERAPY is considered as a noninvasive method, most photosensitizers are susceptible to ultrasound. Therefore, it is expected that the combination of two activation methods might have a synergistic effect. This probable effect has been investigated in this study.Materials and Methods: This study was conducted on COLON CARCINOMA tumor in Balb/c mice. The tumors were induced by subcutaneous injection of CT26 cells. Ultrasound and light irradiations were performed on tumors 24 hr after injection of liposomal Zn (II)-phthalocyanine. The treatment efficacy was evaluated using daily measurement of the tumor dimensions.Results: Ten days post treatment, relative tumor volumes of all groups were significantly reduced in comparison with the main control group. The best response was observed when one of the two treatment methods had been applied. The longest doubling time of tumor was related to the treatment group namely photodynamic, sonodynamic and combination technique, while the shortest belonged to the control group.Conclusion: This study showed that liposomal Zn phthalocyanine is both photosensitizer and sonosensitizer. Photodynamic and sonodynamic therapies can be efficient in retarding tumor growth rate. In this study, the combination of two methods didn’t show any improvement in therapeutic outcomes. It is predicted that latest results are related to the treatments sequence and could be optimized in the future.

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APA: Copy

SAZGARNIA, AMENEH, BAKHSHIZADEH, MARYAM, RAJABI, OMID, KHOOEI, ALI REZA, & ESMAILY, HABIBOLLAH. (2011). EFFECTS OF COMBINED SONODYNAMIC AND PHOTODYNAMIC THERAPIES ON A COLON CARCINOMA TUMOR MODEL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(3 (50)), 205-212. SID. https://sid.ir/paper/567815/en

Vancouver: Copy

SAZGARNIA AMENEH, BAKHSHIZADEH MARYAM, RAJABI OMID, KHOOEI ALI REZA, ESMAILY HABIBOLLAH. EFFECTS OF COMBINED SONODYNAMIC AND PHOTODYNAMIC THERAPIES ON A COLON CARCINOMA TUMOR MODEL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(3 (50)):205-212. Available from: https://sid.ir/paper/567815/en

IEEE: Copy

AMENEH SAZGARNIA, MARYAM BAKHSHIZADEH, OMID RAJABI, ALI REZA KHOOEI, and HABIBOLLAH ESMAILY, “EFFECTS OF COMBINED SONODYNAMIC AND PHOTODYNAMIC THERAPIES ON A COLON CARCINOMA TUMOR MODEL,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 3 (50), pp. 205–212, 2011, [Online]. Available: https://sid.ir/paper/567815/en

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