THE IMPACT OF GENERIC FORM OF CLOPIDOGREL ON CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY ARTERY STENT: RESULTS OF THE OPCES STUDY

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KHOSRAVI ALI REZA; POURMOQHADAS MASOUD; OSTOVAN MOHAMMAD; KIANI MEHR GILDA; GHARIPOUR MOJGAN; ZAKERI HABIB; SOLEIMANI BAHRAM; NAMDARI MEHRDAD; HASSANZADEH MEHDI; TAVASOLLI ALI AKBAR; GHAFFARI SAMAD; KHALEDIFAR ARSALAN; ROGHANI FARSHAD; KHOSRAVI MOHAMMAD REZA; SARAMI SHAHROOZ; KOJOURI JAVAD; NORI FATEMEH; KHOSRAVI ELHAM; JOZAN MAHNAZ; SARRAFZADEGAN NIZAL

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:5 Page(s): 640-650

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Title

THE IMPACT OF GENERIC FORM OF CLOPIDOGREL ON CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY ARTERY STENT: RESULTS OF THE OPCES STUDY

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CARDIOVASCULAR EVENTS

CORONARY ARTERY STENTS

OPCES

Abstract

BACKGROUND: To compare the early and late CARDIOVASCULAR EVENTS as well as side effects of Osvix, a generic form of Clopidogrel versus Plavix regimens in patients with chronic stable angina, undergoing bare metal stent (BMS) or drug eluting stent (DES) placement, this study was carried out.METHODS: A total of 442 patients with chronic stable angina who were scheduled for elective percutaneous coronary intervention (PCI) were included in a randomized, double blind, multi-centric clinical trial being performed in 6 distinct university hospitals in 5 cities of Iran from March 2007 to November 2009. Baseline, demographic and history of risk factors were recorded using the patients’ medical charts. Stenting procedure was performed via transfemoral approach using low osmolar contrast agents. Patients underwent BMS or DES placements based on the physician selection and were randomly assigned to Osvix or Plavix groups. Patients were followed by telephone in 0 and 6 months intervals regarding the major adverse CARDIOVASCULAR EVENTS (MACE) including death, myocardial infarction, in-stent thrombosis, stroke, target lesion revascularization, and target vascular revascularization. Angina episodes, bleeding, liver enzymes, neutrophils and platelets count were also assessed in these intervals.RESULTS: There was not any significant difference between these two groups regarding the baseline characteristics. In the DES group, the 6-month mortality rate and the incidence of MACE in Osvix and Plavix groups were 0.9% and 1.9% (p=0.61) and 1.8% and 4.9% (p=0.26), respectively. During the follow up period after DES or BMS placement, there wasn’t any significant difference regarding neutrophil and platelet counts or liver enzymes between study groups.CONCLUSIONS: Using Osvix and Plavix are followed by similar major CARDIOVASCULAR EVENTS and side-effect profile in patients undergoing PCI.

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APA: Copy

KHOSRAVI, ALI REZA, POURMOQHADAS, MASOUD, OSTOVAN, MOHAMMAD, KIANI MEHR, GILDA, GHARIPOUR, MOJGAN, ZAKERI, HABIB, SOLEIMANI, BAHRAM, NAMDARI, MEHRDAD, HASSANZADEH, MEHDI, TAVASOLLI, ALI AKBAR, GHAFFARI, SAMAD, KHALEDIFAR, ARSALAN, ROGHANI, FARSHAD, KHOSRAVI, MOHAMMAD REZA, SARAMI, SHAHROOZ, KOJOURI, JAVAD, NORI, FATEMEH, KHOSRAVI, ELHAM, JOZAN, MAHNAZ, & SARRAFZADEGAN, NIZAL. (2011). THE IMPACT OF GENERIC FORM OF CLOPIDOGREL ON CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY ARTERY STENT: RESULTS OF THE OPCES STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(5), 640-650. SID. https://sid.ir/paper/567844/en

Vancouver: Copy

KHOSRAVI ALI REZA, POURMOQHADAS MASOUD, OSTOVAN MOHAMMAD, KIANI MEHR GILDA, GHARIPOUR MOJGAN, ZAKERI HABIB, SOLEIMANI BAHRAM, NAMDARI MEHRDAD, HASSANZADEH MEHDI, TAVASOLLI ALI AKBAR, GHAFFARI SAMAD, KHALEDIFAR ARSALAN, ROGHANI FARSHAD, KHOSRAVI MOHAMMAD REZA, SARAMI SHAHROOZ, KOJOURI JAVAD, NORI FATEMEH, KHOSRAVI ELHAM, JOZAN MAHNAZ, SARRAFZADEGAN NIZAL. THE IMPACT OF GENERIC FORM OF CLOPIDOGREL ON CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY ARTERY STENT: RESULTS OF THE OPCES STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(5):640-650. Available from: https://sid.ir/paper/567844/en

IEEE: Copy

ALI REZA KHOSRAVI, MASOUD POURMOQHADAS, MOHAMMAD OSTOVAN, GILDA KIANI MEHR, MOJGAN GHARIPOUR, HABIB ZAKERI, BAHRAM SOLEIMANI, MEHRDAD NAMDARI, MEHDI HASSANZADEH, ALI AKBAR TAVASOLLI, SAMAD GHAFFARI, ARSALAN KHALEDIFAR, FARSHAD ROGHANI, MOHAMMAD REZA KHOSRAVI, SHAHROOZ SARAMI, JAVAD KOJOURI, FATEMEH NORI, ELHAM KHOSRAVI, MAHNAZ JOZAN, and NIZAL SARRAFZADEGAN, “THE IMPACT OF GENERIC FORM OF CLOPIDOGREL ON CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY ARTERY STENT: RESULTS OF THE OPCES STUDY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 5, pp. 640–650, 2011, [Online]. Available: https://sid.ir/paper/567844/en

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