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Title

GENOTYPING OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR-γ) POLYMORPHISM (PRO12ALA) IN IRANIAN POPULATION

Pages

  291-296

Abstract

 BACKGROUND: The peroxisome proliferator-activated receptor-g (PPAR-g) is a nuclear hormone receptor. It is predominantly expressed in adipose tissue and as a receptor for thiazolidinediones, it has drawn attentions towards itself as a key molecule to trigger pathways involving in some diseases such as cancers, type 2 diabetes, inflammations and osteoporosis.A proline changed to alanine in codon 12 of PPAR-g gene (Pro12Ala) has been known to be responsible for decreased risk of type 2 diabetes. The aim of the present study is to investigate the frequency of Pro12Ala POLYMORPHISM in PPAR-g in healthy IRANian population to compare with other populations. Understanding this POLYMORPHISM may help us in better diagnosis, prevention, and therapeutic approaches toward a better management of diseases such as type 2 diabetes and osteoporosis.METHODS: 128 healthy volunteers were enrolled in this study. To determine single nucleotide POLYMORPHISMs (SNPs), we did real time polymerase chain reaction (RT-PCR), using TaqMan allelic discrimination assays.RESULTS: Genotype frequencies for PPAR-g gene Pro12Ala (rs1801282) POLYMORPHISM were 0.86 for CC, 0.14 for CG, 0.00 for GG while allelic frequencies were 0.93 and 0.0.07 for C and G, respectively.CONCLUSIONS: There are statistical differences between the distribution of the PPAR-g-2 Pro12Ala POLYMORPHISM in other populations and IRANian population.

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    APA: Copy

    NAMVARAN, FATEMEH, RAHIMI MOGHADDAM, PARVANEH, & AZARPIRA, NEGAR. (2011). GENOTYPING OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR-γ) POLYMORPHISM (PRO12ALA) IN IRANIAN POPULATION. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(3), 291-296. SID. https://sid.ir/paper/568375/en

    Vancouver: Copy

    NAMVARAN FATEMEH, RAHIMI MOGHADDAM PARVANEH, AZARPIRA NEGAR. GENOTYPING OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR-γ) POLYMORPHISM (PRO12ALA) IN IRANIAN POPULATION. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(3):291-296. Available from: https://sid.ir/paper/568375/en

    IEEE: Copy

    FATEMEH NAMVARAN, PARVANEH RAHIMI MOGHADDAM, and NEGAR AZARPIRA, “GENOTYPING OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR-γ) POLYMORPHISM (PRO12ALA) IN IRANIAN POPULATION,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 3, pp. 291–296, 2011, [Online]. Available: https://sid.ir/paper/568375/en

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