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Information Journal Paper

Title

THE GENETIC BASES OF UTERINE FIBROIDS; A REVIEW

Pages

  181-191

Abstract

 Uterine leiomyomas/fibroids are the most common pelvic tumors of the female genital tract. The initiators remaining unknown, ESTROGENs and PROGESTERONE are considered as promoters of fibroid growth. Fibroids are monoclonal tumors showing 40-50% karyotypically detectable CHROMOSOMAL abnormalities. Cytogenetic aberrations involving chromosomes 6, 7, 12 and 14 constitute the major chromosome abnormalities seen in leiomyomata. This has led to the discovery that disruptions or dysregulations of HMGIC and HMGIY genes contribute to the development of these tumors. Genes such asRAD51L1 act as translocation partners to HMGIC and lead to disruption of gene structure leading to the pathogenesis of UTERINE FIBROIDS. The mechanism underlying this disease is yet to be identified. The occurrence of PCOLCE amid a cluster of at least eight Alu sequences is potentially relevant to the possible involvement of PCOLCE in the 7q22 rearrangements that occur in many leiomyomata. PCOLCE is implicated in cell growth processes. Involvement of Alu sequences in rearrangements can lead to the disruption of this gene and, hence, loss of control for gene expression leading to uncontrolled cell growth. This can also lead to the formation of fibroids.Though, cytogenetics provides a broad perspective on uterine fibroid formation, further molecular analysis is required to understand the etiopathogenesis of UTERINE FIBROIDS.

Cites

References

Cite

APA: Copy

MEDIKARE, VERONICA, KANDUKURI, LAKSHMI RAO, VENKATESHWARI, ANANTHAPUR, DEENADAYAL, MAMATA, & NALLARI, PRATIBHA. (2011). THE GENETIC BASES OF UTERINE FIBROIDS; A REVIEW. JOURNAL OF REPRODUCTION AND INFERTILITY, 12(3 (48)), 181-191. SID. https://sid.ir/paper/568530/en

Vancouver: Copy

MEDIKARE VERONICA, KANDUKURI LAKSHMI RAO, VENKATESHWARI ANANTHAPUR, DEENADAYAL MAMATA, NALLARI PRATIBHA. THE GENETIC BASES OF UTERINE FIBROIDS; A REVIEW. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2011;12(3 (48)):181-191. Available from: https://sid.ir/paper/568530/en

IEEE: Copy

VERONICA MEDIKARE, LAKSHMI RAO KANDUKURI, ANANTHAPUR VENKATESHWARI, MAMATA DEENADAYAL, and PRATIBHA NALLARI, “THE GENETIC BASES OF UTERINE FIBROIDS; A REVIEW,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 12, no. 3 (48), pp. 181–191, 2011, [Online]. Available: https://sid.ir/paper/568530/en

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