PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON THE HEARING OF RABBITS EXPOSED TO NOISE AND CARBON MONOXIDE

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SALEHI NEGIN; AKBARI MEHDI; MOTALEBI KASHANI MASOUD; HAGHANI HAMID

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Journal Paper

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Journal: Auditory and Vestibular Research Journal Year:2011 | Volume:20 | Issue:1 (35) Page(s): 36-46

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Title

PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON THE HEARING OF RABBITS EXPOSED TO NOISE AND CARBON MONOXIDE

Author(s)

SALEHI NEGIN | AKBARI MEHDI | MOTALEBI KASHANI MASOUD | HAGHANI HAMID | Issue Writer Certificate

Keywords

N-ACETYLCYSTEINE

DISTORTION PRODUCT OTOACOUSTIC EMISSIONS

NOISE

CARBON MONOXIDE

Abstract

Background and Aim: One of the chemical pollutions which is frequently common in industry-other than NOISE is CARBON MONOXIDE. The present study aimed to assess the putative protective effect of Nacetylcysteine on the function of outer hair cells of rabbits exposed simultaneously to NOISE and CARBON MONOXIDE.Methods: 24 male rabbits are entered in this interventional study. After obtaining baseline DISTORTION PRODUCT OTOACOUSTIC EMISSIONS, rabits were randomely devided into four groups. The groups Included: exposed with NOISE and received saline, exposed with NOISE and CARBON MONOXIDE and received saline, exposed with NOISE and received N-ACETYLCYSTEINE, and exposed with NOISE and CARBON MONOXIDE and received N-ACETYLCYSTEINE. Subsequently, they were evaluated again with DISTORTION PRODUCT OTOACOUSTIC EMISSIONS in two stages (two hours and one week after the exposure). Data were recorded and analyzed using paired and independent sample t-tests.Results: Exposure to NOISE, and also simultaneous exposure to NOISE and CARBON MONOXIDE, and moreover using N-ACETYLCYSTEINE in both groups, produced significant changes in DISTORTION PRODUCT OTOACOUSTIC EMISSIONS amplitudes (p<0.005).Conclusion: The findings of the present research reveal that simultaneous exposure to NOISE and CARBON MONOXIDE may potentiate NOISE induced hearing loss. In addition, utilizing N-ACETYLCYSTEINE can be used as a preventive agent for NOISE induced hearing loss and to avoid its potentiation with CARBON MONOXIDE.

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APA: Copy

SALEHI, NEGIN, AKBARI, MEHDI, MOTALEBI KASHANI, MASOUD, & HAGHANI, HAMID. (2011). PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON THE HEARING OF RABBITS EXPOSED TO NOISE AND CARBON MONOXIDE. AUDITORY AND VESTIBULAR RESEARCH, 20(1 (35)), 36-46. SID. https://sid.ir/paper/568861/en

Vancouver: Copy

SALEHI NEGIN, AKBARI MEHDI, MOTALEBI KASHANI MASOUD, HAGHANI HAMID. PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON THE HEARING OF RABBITS EXPOSED TO NOISE AND CARBON MONOXIDE. AUDITORY AND VESTIBULAR RESEARCH[Internet]. 2011;20(1 (35)):36-46. Available from: https://sid.ir/paper/568861/en

IEEE: Copy

NEGIN SALEHI, MEHDI AKBARI, MASOUD MOTALEBI KASHANI, and HAMID HAGHANI, “PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON THE HEARING OF RABBITS EXPOSED TO NOISE AND CARBON MONOXIDE,” AUDITORY AND VESTIBULAR RESEARCH, vol. 20, no. 1 (35), pp. 36–46, 2011, [Online]. Available: https://sid.ir/paper/568861/en

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