مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EVALUATION OF PROTECTIVE EFFECTS OF NANO-FORMULATED SILYMARIN AGAINST UV RADIATION ON GUINEA PIG SKIN

Pages

  86-96

Abstract

 Background: As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. SILYMARIN has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.Objective: In present study, nano-formulated SILYMARIN was used in a cream, and its effects were investigated against destructive effects of UV rays.Methods: SILYMARIN standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined; Group 1; without any treatment (control), Group 2; Vaseline, Group 3; nano-formulated SILYMARIN extract cream, and Group 4; SILYMARIN-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm2. Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.Results: SILYMARIN NANO-FORMULATION was effective in decreasing both physical damages and histopathological injuries significantly.Conclusion: from the observed results, it can be concluded that the cream containing nano-formulated SILYMARIN can prevent UV radiation lesions better than pure SILYMARIN.

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    APA: Copy

    AHMADI ASHTIANI, H.R., REZAZADEH, SH., BARKHOURDARI, E., HEKMAT NAZEMI, N., BAGHAEI, M., BOKAEI, S., & RASTEGAR, H.. (2010). EVALUATION OF PROTECTIVE EFFECTS OF NANO-FORMULATED SILYMARIN AGAINST UV RADIATION ON GUINEA PIG SKIN. JOURNAL OF MEDICINAL PLANTS, 9(SUPPLEMENT 6), 86-96. SID. https://sid.ir/paper/568928/en

    Vancouver: Copy

    AHMADI ASHTIANI H.R., REZAZADEH SH., BARKHOURDARI E., HEKMAT NAZEMI N., BAGHAEI M., BOKAEI S., RASTEGAR H.. EVALUATION OF PROTECTIVE EFFECTS OF NANO-FORMULATED SILYMARIN AGAINST UV RADIATION ON GUINEA PIG SKIN. JOURNAL OF MEDICINAL PLANTS[Internet]. 2010;9(SUPPLEMENT 6):86-96. Available from: https://sid.ir/paper/568928/en

    IEEE: Copy

    H.R. AHMADI ASHTIANI, SH. REZAZADEH, E. BARKHOURDARI, N. HEKMAT NAZEMI, M. BAGHAEI, S. BOKAEI, and H. RASTEGAR, “EVALUATION OF PROTECTIVE EFFECTS OF NANO-FORMULATED SILYMARIN AGAINST UV RADIATION ON GUINEA PIG SKIN,” JOURNAL OF MEDICINAL PLANTS, vol. 9, no. SUPPLEMENT 6, pp. 86–96, 2010, [Online]. Available: https://sid.ir/paper/568928/en

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