MUTATION ANALYSIS OFTP53 TUMOR SUPPRESSOR GENE IN COLORECTAL CANCER IN PATIENTS FROM IRAN (KERMAN PROVINCE)

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LOHRASBI NEJAD AZADEH; YAGHOOBI MOHAMMAD MEHDI

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2012 | Volume:15 | Issue:1 Page(s): 683-690

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Title

MUTATION ANALYSIS OFTP53 TUMOR SUPPRESSOR GENE IN COLORECTAL CANCER IN PATIENTS FROM IRAN (KERMAN PROVINCE)

Author(s)

LOHRASBI NEJAD AZADEH | YAGHOOBI MOHAMMAD MEHDI | Issue Writer Certificate

Keywords

COLORECTAL CANCER

POINT MUTATION

TP35 TUMOR SUPPRESSOR GENE

Abstract

Objective(s): P53is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. The aim of this study was to reveal mutations ofTP53 in COLORECTAL CANCER in Kerman province.Materials and Methods: A total of Forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage IIIA, were selected. Three exons 5, 7 and 8 ofP53 were amplified by PCR technique and sequenced directly.Results: The results showed two deletions at codon 140 and 142 in one tumor sample. GAT→AAT mutation at codon 184, and CGG→TGG mutation at codon 248 were seen in some tumor samples. Some mutations were also observed in middle of intron 7 in some tumor or normal tissues.Conclusion: Some of those patients with mutation inP53 gene had metastasis in other organs. Therefore, genetic test before chemotherapy is helpful for successful treatment.

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APA: Copy

LOHRASBI NEJAD, AZADEH, & YAGHOOBI, MOHAMMAD MEHDI. (2012). MUTATION ANALYSIS OFTP53 TUMOR SUPPRESSOR GENE IN COLORECTAL CANCER IN PATIENTS FROM IRAN (KERMAN PROVINCE). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(1), 683-690. SID. https://sid.ir/paper/569651/en

Vancouver: Copy

LOHRASBI NEJAD AZADEH, YAGHOOBI MOHAMMAD MEHDI. MUTATION ANALYSIS OFTP53 TUMOR SUPPRESSOR GENE IN COLORECTAL CANCER IN PATIENTS FROM IRAN (KERMAN PROVINCE). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(1):683-690. Available from: https://sid.ir/paper/569651/en

IEEE: Copy

AZADEH LOHRASBI NEJAD, and MOHAMMAD MEHDI YAGHOOBI, “MUTATION ANALYSIS OFTP53 TUMOR SUPPRESSOR GENE IN COLORECTAL CANCER IN PATIENTS FROM IRAN (KERMAN PROVINCE),” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 1, pp. 683–690, 2012, [Online]. Available: https://sid.ir/paper/569651/en

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