A COMPARATIVE STUDY UPON THE THERAPEUTIC INDICES OF SOME NATURAL AND SYNTHETIC ANTI-INFLAMMATORY AGENTS

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KHODADADI ALI; PIPELZADEH MOHAMMAD HASSAN; AGHEL NASRIN; ESMAEILIAN MAJID; ZALI IMAN

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2011 | Volume:14 | Issue:4 (51) Page(s): 340-348

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Title

A COMPARATIVE STUDY UPON THE THERAPEUTIC INDICES OF SOME NATURAL AND SYNTHETIC ANTI-INFLAMMATORY AGENTS

Author(s)

Keywords

ANTINFLAMMATORY AGENTS

CYTOTOXICITY

GELATINASE

MATRIX-METALLOPROTEINASES

THERAPUETIC INDEX

ZYMOGRAPHY

Abstract

Objective (s): The aim of the present study was to compare the therapeutic indices of several agents used in treatment of inflammatory conditions which included: Vitamin E, hydro-alcoholic extracts of Glycyrrhiza glabra, Matricaria aurea, dexamethasone, piroxicam and diclofenac using Wehi-164 fibrosarcoma cells.Materials and Methods: CYTOTOXICITY evaluation was based on vital dye exclusion assay. MATRIX-METALLOPROTEINASES inhibition (MMPI) was assessed by GELATINASE ZYMOGRAPHY method. The collected data were used to estimate the IC50 (50% MMPI concentration), LC50 (50% CYTOTOXICITY concentration) and the therapeutic index (LC50/IC50).Results: Among the natural anti-inflammatory agents used, M. aurea was the least toxic and the most effective inhibitor of MMP. Vitamin E not only increased MMP activity, but also was the most toxic of all the agents tested. Next in terms of toxicity to vitamin E was G. glabra. Diclofenac was more toxic than both piroxicam and dexamethasone.Conclusion: Findings from this study suggest that medicinal plants reputed to have anti-inflammatory properties are not equally effective and safe. In order to assess the implications of these findings, furtherin vitro and in vivo studies are needed.

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APA: Copy

KHODADADI, ALI, PIPELZADEH, MOHAMMAD HASSAN, AGHEL, NASRIN, ESMAEILIAN, MAJID, & ZALI, IMAN. (2011). A COMPARATIVE STUDY UPON THE THERAPEUTIC INDICES OF SOME NATURAL AND SYNTHETIC ANTI-INFLAMMATORY AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(4 (51)), 340-348. SID. https://sid.ir/paper/569684/en

Vancouver: Copy

KHODADADI ALI, PIPELZADEH MOHAMMAD HASSAN, AGHEL NASRIN, ESMAEILIAN MAJID, ZALI IMAN. A COMPARATIVE STUDY UPON THE THERAPEUTIC INDICES OF SOME NATURAL AND SYNTHETIC ANTI-INFLAMMATORY AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(4 (51)):340-348. Available from: https://sid.ir/paper/569684/en

IEEE: Copy

ALI KHODADADI, MOHAMMAD HASSAN PIPELZADEH, NASRIN AGHEL, MAJID ESMAEILIAN, and IMAN ZALI, “A COMPARATIVE STUDY UPON THE THERAPEUTIC INDICES OF SOME NATURAL AND SYNTHETIC ANTI-INFLAMMATORY AGENTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 4 (51), pp. 340–348, 2011, [Online]. Available: https://sid.ir/paper/569684/en

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