APPLICATION OF RADIOPROTECTIVE AGENTS IN CANCER TREATMENT

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MIHANDOUST EHSAN; SHIRAZI ALIREZA

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2010 | Volume:18 | Issue:SUPPLEMENT 1 Page(s): 107-107

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Information Journal Paper

Title

APPLICATION OF RADIOPROTECTIVE AGENTS IN CANCER TREATMENT

Author(s)

MIHANDOUST EHSAN | SHIRAZI ALIREZA | Issue Writer Certificate

Keywords

RADIOPROTECTORS

AMINOTHIOLS

ANTIOXIDANTS

AMIFOSTIN

VITAMIN E

Abstract

Radiation exposures can occur without any prior warning in the following settings: radiography, nuclear medicine, radiotherapy, radiological imaging, radionuclide production, biomedical research, military, public domain, transportation, nuclear reactors, space flights etc. patients may be exposed to ionizing radiation during radiotherapy or following exposure to radionuclides in nuclear medicine. There is, therefore, a need to protect humans against planned (e.g. radiotherapy and nuclear medicine) and unplanned (e.g. industrial nuclear accident or nuclear war) exposures is necessary. RADIOPROTECTORS are compounds that have the ability to reduce the biological effects of ionizing radiation on normal tissues, including lethality, mutagenicity and carcinogenicity, and have applications in clinical oncology, space travel, radiation site clean-up, radiological terrorism and military scenarios. The RADIOPROTECTORS can elicit their action by various mechanisms such as: suppressing the formation of free radicals, inducing the cellular RADIOPROTECTORS such as superoxide dismutase (SOD), enhancing the DNA repair and inducting hypoxia in the tissues. The most effective RADIOPROTECTORS developed so far are AMINOTHIOLS and their derivatives. Some of these compounds have been successfully used to prevent complications of radiation therapy in patients with cancer. Unfortunately, all of the AMINOTHIOLS have toxic side effects that limit their use in medical practice.Results from animal experiments indicate that antioxidant nutrients, like vitamin A, C, E and selenium compounds, are protective against lethality and other radiation effects but to a lesser degree than most synthetic protectors. a large number of plants contain antioxidant phytochemicals reported to be radioprotective in various model systems. Clinical trials have not yet been undertaken with most herbal RADIOPROTECTORS. If these are performed, herbal radioprotective drugs for human use from several of plants may soon be available. Therefore, the activity of numerous investigators is directed towards finding an effective radioprotective agents that would successfully prevent development of radiation syndrome and protect cells and tissue from deleterious effects of radiation. most of the compounds failed in their transition from laboratory to clinic. Acute toxicity and their inability to differentiate between tumor and normal cells are the main reasons for their failure in clinical applications. However, Early research on radiation protection has unraveled the basic mechanisms and yielded a large number of radioprotecting compounds.

Cites

EVALUATION OF RADIO-PROTECTIVE EFFECT OF MELATONIN ON WHOLE BODY IRRADIATION INDUCED LIVER TISSUE DAMAGE

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APA: Copy

MIHANDOUST, EHSAN, & SHIRAZI, ALIREZA. (2010). APPLICATION OF RADIOPROTECTIVE AGENTS IN CANCER TREATMENT. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(SUPPLEMENT 1), 107-107. SID. https://sid.ir/paper/570997/en

Vancouver: Copy

MIHANDOUST EHSAN, SHIRAZI ALIREZA. APPLICATION OF RADIOPROTECTIVE AGENTS IN CANCER TREATMENT. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(SUPPLEMENT 1):107-107. Available from: https://sid.ir/paper/570997/en

IEEE: Copy

EHSAN MIHANDOUST, and ALIREZA SHIRAZI, “APPLICATION OF RADIOPROTECTIVE AGENTS IN CANCER TREATMENT,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. SUPPLEMENT 1, pp. 107–107, 2010, [Online]. Available: https://sid.ir/paper/570997/en

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