مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

461
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

268
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

EFFECT OF MORPHINE WITHDRAWAL SYNDROME ON CEREBRAL ISCHEMIA OUTCOME IN RATS

Pages

  1-8

Abstract

 Objective(s) Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. In the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. Materials and Methods ADDICTION was induced by progressive incremental doses of morphine over 7 days. Behavioral signs of withdrawal were observed 24, 48 and 72 hr after morphine deprivation and total withdrawal score was determined. CEREBRAL ISCHEMIA was induced 18-22 hr after the last morphine injection by placing a natural clot into the middle cerebral artery (MCA). Neurological deficits were evaluated at 2, 24 and 48 hr after ischemia induction, and infarct size and brain edema were determined at 48 hr after stroke. Results Morphine withdrawal animals showed a significant increase in total withdrawal score and decrease of weight gain during the 72 hr after the last morphine injection. Compared to the addicted and control animals, infarct volume and brain edema were significantly increased in the morphine deprived animals (P< 0.05) at 48 hr after CEREBRAL ISCHEMIA. Also, neurological deficits were higher in the morphine-withdrawn rats at 48 hr after stroke (P< 0.05). Conclusion Our data indicates that spontaneous withdrawal syndrome may worsen stroke outcomes. Further investigations are necessary to elucidate mechanisms of opiate withdrawal syndrome on stroke.

Cites

References

Cite

APA: Copy

ALLAHTAVAKOLI, MOHAMMAD, MOLOUDI, RUHOLLAH, REZVANI, MOHAMMAD EBRAHIM, & SHAMSIZADEH, ALI. (2011). EFFECT OF MORPHINE WITHDRAWAL SYNDROME ON CEREBRAL ISCHEMIA OUTCOME IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(1 (48)), 1-8. SID. https://sid.ir/paper/572123/en

Vancouver: Copy

ALLAHTAVAKOLI MOHAMMAD, MOLOUDI RUHOLLAH, REZVANI MOHAMMAD EBRAHIM, SHAMSIZADEH ALI. EFFECT OF MORPHINE WITHDRAWAL SYNDROME ON CEREBRAL ISCHEMIA OUTCOME IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(1 (48)):1-8. Available from: https://sid.ir/paper/572123/en

IEEE: Copy

MOHAMMAD ALLAHTAVAKOLI, RUHOLLAH MOLOUDI, MOHAMMAD EBRAHIM REZVANI, and ALI SHAMSIZADEH, “EFFECT OF MORPHINE WITHDRAWAL SYNDROME ON CEREBRAL ISCHEMIA OUTCOME IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 1 (48), pp. 1–8, 2011, [Online]. Available: https://sid.ir/paper/572123/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button