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Information Journal Paper

Title

RELATIONSHIP BETWEEN GAMMA-GLUTAMYL TRANSFERASE AND GLUCOSE INTOLERANCE IN FIRST DEGREE RELATIVES OF TYPE 2 DIABETICS PATIENTS

Pages

  123-129

Abstract

 BACKGROUND: Considering that serum gamma-glutamyl transferase (GGT) activity could reflect several different processes relevant to diabetes pathogenesis and the increasing rate of TYPE 2 diabetes worldwide, the aim of this study was to assess the association between serum GGT concentrations and GLUCOSE INTOLERANCE, in the first-degree relatives (FDR) of TYPE 2 diabetic patients.METHODS: In this descriptive study, 30-80 years old, non diabetic FDRs of TYPE 2 diabetic patients were studied. Serum GGT was measured by enzymatic photometry method in all studied population. The relationship between GGT and GLUCOSE INTOLERANCE status (normal, prediabetic and diabetics) was evaluated.RESULTS: During this study 551 non-diabetic FDRs of TYPE 2 diabetic patients were studied. Mean of GGT was 25.3 ± 12.1 IU/L. According to glucose tolerance test, 153 were normal and 217 and 181 were diabetic and prediabetic respectively. Mean of GGT in normal, prediabetic and diabetic patients was 23.5 ± 15.9 IU/L, 29.1 ± 28.1 IU/L and 30.9 ± 24.8 IU/L respectively (p=0.000). The proportion of prediabetic and diabetic patients was higher in higher quartile of GGT and there was a significant correlation between GGT and BMI, HbA1c, FPG, cholesterol, LDL-C, and triglyceride (p < 0.05). There was a significant relation between GGT and area under the curve (AUC) of oral glucose tolerance test (p=0.00).CONCLUSIONS: Measurement of GGT in FDRs of TYPE 2 diabetic patients may be useful in assessing the risk of diabetes; those with chronically high levels of GGT should be considered as high risk group for diabetes.

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    APA: Copy

    HAGHIGHI, SASSAN, AMINI, MASSOUD, POURNAGHSHBAND, ZAHRA, AMINI, PEYVAND, & HOVSEPIAN, SILVA. (2011). RELATIONSHIP BETWEEN GAMMA-GLUTAMYL TRANSFERASE AND GLUCOSE INTOLERANCE IN FIRST DEGREE RELATIVES OF TYPE 2 DIABETICS PATIENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(2), 123-129. SID. https://sid.ir/paper/572143/en

    Vancouver: Copy

    HAGHIGHI SASSAN, AMINI MASSOUD, POURNAGHSHBAND ZAHRA, AMINI PEYVAND, HOVSEPIAN SILVA. RELATIONSHIP BETWEEN GAMMA-GLUTAMYL TRANSFERASE AND GLUCOSE INTOLERANCE IN FIRST DEGREE RELATIVES OF TYPE 2 DIABETICS PATIENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(2):123-129. Available from: https://sid.ir/paper/572143/en

    IEEE: Copy

    SASSAN HAGHIGHI, MASSOUD AMINI, ZAHRA POURNAGHSHBAND, PEYVAND AMINI, and SILVA HOVSEPIAN, “RELATIONSHIP BETWEEN GAMMA-GLUTAMYL TRANSFERASE AND GLUCOSE INTOLERANCE IN FIRST DEGREE RELATIVES OF TYPE 2 DIABETICS PATIENTS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 2, pp. 123–129, 2011, [Online]. Available: https://sid.ir/paper/572143/en

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