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Information Journal Paper

Title

THE PROTECTIVE EFFECTS OF EXOGENOUS MELATONIN ON NICOTINE-INDUCED CHANGES IN MOUSE OVARIAN FOLLICLES

Pages

  143-150

Abstract

 Background: NICOTINE exposure causes impaired fertility and ovarian dysfunction.The aim of this study was to investigate the possible protective role of MELATONIN, which is known as an antioxidant agent on altered ovarian functions upon NICOTINE exposure.Methods: A total of 32 female adult NMRI mice were divided randomly into four groups (n=8). The control group received vehicle, while group 2 received NICOTINE (40m g/kg) for 15 days and group 3 MELATONIN (10 mg/kg) for 5 days. Group 4 received both NICOTINE (40m g/kg) and MELATONIN (10 mg/kg) for the same periods. All animals were treated intraperitoneally. After autopsy on the 16th day, histopathological and morphometrical examinations were performed and serum estradiol concentrations were measured. The data were analyzed using ANOVA and Tukey post hoc test. A value of p<0.05 was considered significant.Results: NICOTINE significantly reduced the number of pre-antral and antral follicles, as well as estradiol concentration compared to the control group (p<0.05). However, the decrease in the number of primordial follicles was not significant in the NICOTINE treated group. A significant increase in the atretic follicles were observed in group 2 compared to the control group (p<0.05). Moreover, MELATONIN caused a marked normalization in the number of OVARIAN FOLLICLEs and estradiol levels in group 4 compared to group 2.Conclusion: The results from this study suggest that MELATONIN may have a protective effect against NICOTINE-induced ovarian changes on the number of different stages of follicle growth.

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    APA: Copy

    MOHAMMADGHASEMI, FAHIMEH, KHAJEH JAHROMI, SINA, HAJIZADEH, HADI, HOMAFAR, MOHAMMAD AMIN, & SAADAT, NAZANIN. (2012). THE PROTECTIVE EFFECTS OF EXOGENOUS MELATONIN ON NICOTINE-INDUCED CHANGES IN MOUSE OVARIAN FOLLICLES. JOURNAL OF REPRODUCTION AND INFERTILITY, 13(3 (52)), 143-150. SID. https://sid.ir/paper/572465/en

    Vancouver: Copy

    MOHAMMADGHASEMI FAHIMEH, KHAJEH JAHROMI SINA, HAJIZADEH HADI, HOMAFAR MOHAMMAD AMIN, SAADAT NAZANIN. THE PROTECTIVE EFFECTS OF EXOGENOUS MELATONIN ON NICOTINE-INDUCED CHANGES IN MOUSE OVARIAN FOLLICLES. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2012;13(3 (52)):143-150. Available from: https://sid.ir/paper/572465/en

    IEEE: Copy

    FAHIMEH MOHAMMADGHASEMI, SINA KHAJEH JAHROMI, HADI HAJIZADEH, MOHAMMAD AMIN HOMAFAR, and NAZANIN SAADAT, “THE PROTECTIVE EFFECTS OF EXOGENOUS MELATONIN ON NICOTINE-INDUCED CHANGES IN MOUSE OVARIAN FOLLICLES,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 13, no. 3 (52), pp. 143–150, 2012, [Online]. Available: https://sid.ir/paper/572465/en

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