مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE EFFECTS OF FEMALE SEX STEROIDS ON GASTRIC SECRETORY RESPONSES OF RAT FOLLOWING TRAUMATIC BRAIN INJURY

Pages

  231-239

Abstract

 Objective(s): Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. The female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. The purpose of this study was to evaluate the role of estradiol and PROGESTERONE on the GASTRIC ACID and PEPSIN levels following traumatic BRAIN INJURY (TBI) induction.Materials and Methods: Diffuse TBI was induced by Marmarou method in female rats. Rats randomly assigned into 9 groups: intact, OVX (ovarectomized rat), Sham+OVX, TBI (intact rats under TBI), TBI+OVX (ovarectomized rats under TBI) and treated OVX rats with vehicle (sesame oil), E2 (estradiol), P4 (progesterone) or E2+P4 combination. The acid content and PEPSIN levels of each gastric washout sample were measured 5days after the TBI induction.Results: There was no significant difference in GASTRIC ACID output between groups either after TBI induction or after treatment with E2 or P4 or E2+P4. Gastric PEPSIN levels were increased in Sham+OVX, TBI (P<0.001) and TBI+OVX (P< 0.05) compared to intact group. Gastric PEPSIN levels were significantly lower in E2 and E2+P4 treated rats than vehicle treated group (P< 0.01). P4 treatment increased gastric PEPSIN level compared to TBI+OVX group (P< 0.05) and this increment was higher than rats that were treated with the E2 and E2+P4 (P<0.01).Conclusion: These results suggest that protective effect of estradiol and E2+P4 combination against mucosal damage after TBI, might be mediated by inhibition of PEPSIN secretion.

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    • Cite

    APA: Copy

    KESHAVARZI, ZAKIEH, KHAKSARI HADAD, MOHAMMAD, ZAHEDI, MOHAMMAD JAVAD, & BAHRAMI, ABBAS. (2011). THE EFFECTS OF FEMALE SEX STEROIDS ON GASTRIC SECRETORY RESPONSES OF RAT FOLLOWING TRAUMATIC BRAIN INJURY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(3 (50)), 231-239. SID. https://sid.ir/paper/572641/en

    Vancouver: Copy

    KESHAVARZI ZAKIEH, KHAKSARI HADAD MOHAMMAD, ZAHEDI MOHAMMAD JAVAD, BAHRAMI ABBAS. THE EFFECTS OF FEMALE SEX STEROIDS ON GASTRIC SECRETORY RESPONSES OF RAT FOLLOWING TRAUMATIC BRAIN INJURY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(3 (50)):231-239. Available from: https://sid.ir/paper/572641/en

    IEEE: Copy

    ZAKIEH KESHAVARZI, MOHAMMAD KHAKSARI HADAD, MOHAMMAD JAVAD ZAHEDI, and ABBAS BAHRAMI, “THE EFFECTS OF FEMALE SEX STEROIDS ON GASTRIC SECRETORY RESPONSES OF RAT FOLLOWING TRAUMATIC BRAIN INJURY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 3 (50), pp. 231–239, 2011, [Online]. Available: https://sid.ir/paper/572641/en

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