COMPARISON OF THE EFFECT OF FENTANYL, SUFENTANIL, ALFENTANIL AND REMIFENTANIL ON CARDIOVASCULAR RESPONSE TO TRACHEAL INTUBATION IN CHILDREN

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MIRESKANDARI SEYED MOHAMAD; ABULAHRAR NAVID; DARABI MOHAMAD ESMAEIL; RAHIMI IMAN; HAJI MOHAMADI FATEMEH; MOVAFEGH ALI

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Journal: Iranian Journal of Pediatrics Year:2011 | Volume:21 | Issue:2 Page(s): 173-180

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Title

COMPARISON OF THE EFFECT OF FENTANYL, SUFENTANIL, ALFENTANIL AND REMIFENTANIL ON CARDIOVASCULAR RESPONSE TO TRACHEAL INTUBATION IN CHILDREN

Author(s)

Keywords

INTUBATION

LARYNGOSCOPY

OPIOID

SUFENTANIL

ALFENTANIL

FENTANYL

REMIFENTANIL

Abstract

Objective: LARYNGOSCOPY and tracheal INTUBATION may cause significant cerebral and systemic hemodynamic responses. Many drugs have been shown to be effective in modifying these hemodynamic responses, including FENTANYL, SUFENTANIL, ALFENTANIL and REMIFENTANIL. The purpose of the current study was to compare the efficacy of FENTANYL, SUFENTANIL, ALFENTANIL and REMIFENTANIL on blunting cardiovascular changes during LARYNGOSCOPY and INTUBATION in children.Methods: Eighty children, 1-6 years old, classified as American Society of Anesthesiologists physical status I and II who were scheduled for elective surgery with general anesthesia and orotracheal INTUBATION, were enrolled in this randomized and double-blinded study. Patients were randomly assigned into four groups of 20 patients. Group F received FENTANYL 1mg/kg-1, group S received SUFENTANIL 0.1 1mg/kg-1, group A received ALFENTANIL 10 mg/kg-1 and group R received REMIFENTANIL 1mg/kg-1 intravenously. After establishment of neuromuscular blockade confirmed with a nerve stimulator, LARYNGOSCOPY and orotracheal INTUBATION were performed 3 min after induction.Hemodynamic variables including systolic and diastolic blood pressure (SAP, DAP) and heart rate (HR) were recorded at base line (before OPIOID administration), before LARYNGOSCOPY and one minute after orotracheal INTUBATION.Findings: The patients' characteristics and LARYNGOSCOPY grade were similar in all groups. There was no significant difference in the mean values of SAP, DAP and HR at each measured time between the four groups. There was significant difference in the mean values of SAP, DAP and HR measured over time in each group.Conclusion: The intravenous FENTANYL attenuated LARYNGOSCOPY-induced SAP, DAP and HR increases better than SUFENTANIL, ALFENTANIL or REMIFENTANIL and hemodynamic stability is better preserved with FENTANYL.

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APA: Copy

MIRESKANDARI, SEYED MOHAMAD, ABULAHRAR, NAVID, DARABI, MOHAMAD ESMAEIL, RAHIMI, IMAN, HAJI MOHAMADI, FATEMEH, & MOVAFEGH, ALI. (2011). COMPARISON OF THE EFFECT OF FENTANYL, SUFENTANIL, ALFENTANIL AND REMIFENTANIL ON CARDIOVASCULAR RESPONSE TO TRACHEAL INTUBATION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 21(2), 173-180. SID. https://sid.ir/paper/572689/en

Vancouver: Copy

MIRESKANDARI SEYED MOHAMAD, ABULAHRAR NAVID, DARABI MOHAMAD ESMAEIL, RAHIMI IMAN, HAJI MOHAMADI FATEMEH, MOVAFEGH ALI. COMPARISON OF THE EFFECT OF FENTANYL, SUFENTANIL, ALFENTANIL AND REMIFENTANIL ON CARDIOVASCULAR RESPONSE TO TRACHEAL INTUBATION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2011;21(2):173-180. Available from: https://sid.ir/paper/572689/en

IEEE: Copy

SEYED MOHAMAD MIRESKANDARI, NAVID ABULAHRAR, MOHAMAD ESMAEIL DARABI, IMAN RAHIMI, FATEMEH HAJI MOHAMADI, and ALI MOVAFEGH, “COMPARISON OF THE EFFECT OF FENTANYL, SUFENTANIL, ALFENTANIL AND REMIFENTANIL ON CARDIOVASCULAR RESPONSE TO TRACHEAL INTUBATION IN CHILDREN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 21, no. 2, pp. 173–180, 2011, [Online]. Available: https://sid.ir/paper/572689/en

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